Considering TRT for Accutane related hormonal changes

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Frizzle

New Member
Hi guys,

I’m Frank from western Europe and I’m new on this forum. I hope you can share your ideas/experiences about HRT after Accutane.

My story: I took Accutane in 1999 (40mg a day / 5 months). The drug greatly reduced my libido and gave me some mental issues like lower mood, anxiety and reduced verbal fluency (all typical hypogonadism-like symptoms). These side effects are chronic, although I believe they improved a bit over the years. Fertility is still good as I have 3 healthy kids.

A few years ago I underwent a complete medical examination, including neurological and hormonal checks. No abnormalities were found then ('in the range' BS). But nevertheless I believe Accutane caused hormonal changes in my body, as Accutane is known to do. I spoke to a few guys with the same problems, who now use TRT and feel better.

I would like to ask advice on treating these symptoms with HRT/TRT. What can I aspect form HRT/TRT?

Thanks in advance for your responses.
 
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Systemlord

Member
I would like to ask advice on treating these symptoms with HRT/TRT. What can I aspect form HRT/TRT?
There's no way to give you a definite answer, especially considering we don't know where you hormones levels currently sit.

Your genetics will determine how you respond to androgens.

These DHT blockers are known to cause problems, some men previously on DHT blockers respond to TRT while others do not.
 

Frizzle

New Member
Yeah I agree for my situation. I have to do new bloodwork first, and then see what happens after HRT.

Nevertheless I would like to hear from other members what they've done to address these Accutane related problems and how HRT works for them.
 

solothesensei

New Member
I've taken 3 rounds of Accutane in my life and each time I felt my energy levels dwindle a bit more.

Now that I'm on HRT I don't feel good on normal doses (100-150mg test) possibly because of long-lasting 5AR downregulation. I feel like complete crap on those doses.

I need at least 180-200mg to feel good. Interestingly, 150mg testosterone + 35mg masteron takes care of the problem, which further leads me to think DHT is indeed the issue.
 

Frizzle

New Member
Thanks for your reply. Very interesting information. I've heard from other Accutane users that they also needed a higher than normal dose. But you have low T without TRT?

I'm on clomid + HCG right now, before moving on to TRT. For the fist time in years I'm feeling good again, like normal. Although my T wasn't very low, I also suspect a low conversion of T to DHT.
 

Frizzle

New Member
Hi guys, finally got some bloodwork done.

Testosterone - 13nmol/l - (range 8,8 - 32,4)
Free testosterone 248 (range 160 - 640)
Estrogen 112 pmol/l (range 0-230)
SHBG 38 nmol/l
Prolactin - 206 me/l - (< 300)
LH 5 E/L

ALAT / GGT / ASAT were all low, so that's good.

Please shed your lights.
 

Systemlord

Member
Hi guys, finally got some bloodwork done.

Testosterone - 13nmol/l - (range 8,8 - 32,4)
Free testosterone 248 (range 160 - 640)
Estrogen 112 pmol/l (range 0-230)
SHBG 38 nmol/l
Prolactin - 206 me/l - (< 300)
LH 5 E/L

ALAT / GGT / ASAT were all low, so that's good.

Please shed your lights.
A Total T of 374 isn’t great, most men would have symptoms at these levels.

There is also a recent study reporting increased hypogonadal symptoms in younger men ≤ 40 years with TT below 400 ng/dL (13.9 nmol/L).
 

Frizzle

New Member
Do you have any evidence isotretinoin causes hypogonadism 22 years later?
Did it with you?

For me, damage was done directly after treatment, also more than 20 years ago. Recently I went to a specialized doctor over here, after trying everything under the sun except HRT. He told me he treated more post-Accutane guys, those guys had one thing in common: 'lower testosterone'. My TT/FT levels were also on the lower side. He prescribed me some Androgel, which I tried for 2 weeks. It made me feel worse and I had to stop in order to finish some important work related stuff.
Before that I was on HCG-->Clomid (in an attempt to restore some of my own production, although my LH level of 5 wasn't low to start with). Clomid made me feel better. I experienced mental calmness, ameliorated stress coping and higher libido, but with more ED strangely. Stopped that because of numbness side effects and twitching eyes. Next step will be a serious TRT protocol.
 

Frizzle

New Member
It's all going to come down to how much damage the Accutane did to your body. Maybe you recover completely, partially or not at all.
Yeah, I know. And I'll post my progress to inform others, just curious what other post Accutane sufferers did to help their condition.
 

Frizzle

New Member
A Total T of 374 isn’t great, most men would have symptoms at these levels.

Beside the lower testosterone, is there anything else that's suspicious?
 

Steve78

Member
I know people who say they have anxiety 20 years post accutane but again, it’s a hard thing to prove.

My TT was 384 at age 29, and I wasn’t on accutane
 

Frizzle

New Member
Indeed after such a long time it's hard to prove this are related / correlated. For me, the side effects started right after finishing the course (only 20! then), so for me it's not that hard to make the connection. Luckily they do not seem to progress and my overall health is still very good. But I would like to address my hypogonadism symptoms due to Accutane.

Are you on TRT?
 

Steve78

Member
Indeed after such a long time it's hard to prove this are related / correlated. For me, the side effects started right after finishing the course (only 20! then), so for me it's not that hard to make the connection. Luckily they do not seem to progress and my overall health is still very good. But I would like to address my hypogonadism symptoms due to Accutane.

Are you on TRT?
Yes, and I love it
 
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