shbg

If there is some ideal T/E2 ratio, what role does SHBG have there? I have extremely low SHBG, so should I reduce or increase ratio, because of different binding affinity.

Long-term TRT patient, current protocol is 154mg/week in EOD SubQ shots (into thigh, belly, hip, etc). I've struggled on and off with digestion issues (constipation) and lack of deep sleep. A few months ago I started intermittent fasting and it's been good for dropping some weight. That combined...

Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study have provided new insights at the population level. A thorough study of...

Hey guys, It seems like this has been a great method to increase libido for many of the members and in particular DHT levels. For those where it has worked when you have introduced cream with normal injections is there a protocol that you found worked best or a cream dosage that was sufficient...

I've tried to see effects of enclomiphene on SHBG levels. Seen a study but lost the link for it. I think it was a study done as part of FDA approval. I've also seen a few different people posting before and after blood test results in a few different forums. It's starting to seem that maybe if...

My current protocol is 30mg Test Cyp eod. Before trt, my shbg was in the 80s n/mol. With every blood test over the past year it has gotten progressively lower 45 n/mol, 35, and now my most recent is 29. Im getting concerned that it might get TOO low (sub 20). Anyone have experience with this...

What's up guys. I'm wondering how many low shbg guys use an a.i. I've never felt 100% dialed in on trt and have been at this on and off for over 10 years. I feel decent on 90mg of test e a week split mwf. I've tried many different frequency and doses and this has me feeling ok with tt of 500...

I have been on TRT for about three years. In January I switched to daily injections in an effort to control hematocrit, acne and sleep issues. I began at 20 mg per day and have slowly decreased my dose down to what is now 14 mg per day under the theory that the lowest possible dose is best. I...

Hey guys, I am going to be trying NDT in the near future to increase my low thyroid numbers and am hoping a side effect may be increased SHBG from what other members have experienced. That said my TT is 1100, FT 29 and DHT 60. Right now my SHBG sits around 16. Say it increases to 30 what kind...

Is 25 nmol litre considered low?

New to the forum and very new to trt (only 10 days in). I've had 4 tests pre trt over 18m and all with shbg with following results: 23 (latest and lowest) , 26, 31, 34 nmol/L. Should I be worried about having low shbg? Currently my protocol is e5d 125mg Sustanon. Do I need to move to EoD or...

Hi everyone ,I « heard »different thought about the effect of injection frequency on shbg For the same dose ,let’s say 200 mg. Injecting everyday instead of once a week for example will it increase or decrease shbg?

I’m currently injecting 80mg once a week but I’m increasing my dose to 100mg. My current SHBG is 23 but I’m concerned this increase will lower it? What do you guys think?

Hey guys, I recently began supplementing with a low dosage of micronized DHEA(10mg daily) to see if I can boost my lower levels. I ran 25mg a day at one point in the past with a cheap version and it caused some estrogen related side effects which I was trying to avoid with a better quality...

Thanks for taking the time. This is a follow up to my thread from last week (Total T > 1000 ng/dl (very high), Free T < 65 pg/ml (very low)). Total and Free same deal as last time, and not surprisingly SHBG is super high. Is there anything else in there I should pay attention to? I'm 40yo, in...

VA didn't have a Dr for me at local clinic, result I got a bunch of test done! I was really struggling with a T dose of 200mg split daily and in anticipation of new bloods I lowered dose to 150mg a week for one week and then to 140mg a week, a game I have to play so VA wont cut my dose. However...

Hey TRT fellows, I’m still struggling to get the best out of my trt journey and have a question that I can’t seem to find a definitive answer for: Is a SHBG of 24.2 nmol/L considered low ? And Would u go with an ED or EOD protocol with a SHBG level similar to mine ? Thank you

Has anyone been successful in decreasing SHBG level by using boron supplement without TRT?if YES, please give details

Hi Everyone, I was wondering if anyone were able to decrease or stop the aromatization of testosterone without the use of AI. If yes, what would be the minimum dosage we need? Does daily injection reduces aromatization? Its hard to find proper dosage for people with low SHBG and they end up...

From my many posts on this forum many people probably know by now that I am a Low SHBG guy (8-18 labcrop range) which manifested after starting TRT 10 yrs ago... I have never gotten dialed in despite numerous changes in Test dosage, injections, etc... It's been a struggle to lose weight despite...

Ok, I just read through the entire Low SHBG sticky thread and have been researching all over this forum regarding low SHBG and Trt dosing... I was able to pull a lab test from 12 years ago prior to starting TRT and I had a SHBG of 44 (lab corp range)... Since starting TRT my SHBG has dropped...

Sex hormone-binding globulin (SHBG) is produced and secreted by the liver into the bloodstream where it binds sex steroids and regulates their bioavailability. Traditionally, body mass index (BMI) was thought to be the major determinant of SHBG concentrations and hyperinsulinemia the main cause...

I've had an issue for the last couple of months now where my TT has not been nearly as high as it used to be given a particular dose of T cyp. Early Feb I saw a 600 off 150mg/week. Last week, 730 off of 182mg/week + 150IU HCG EOD. Last fall, I was at 1200 with 200mg/week. Where the hell could...

PARTICIPATION NEEDED! Of those EM members that have taken nandrolone or are currently taking nandrolone alongside their TRT, we are conducting a small ExcelMale study to help determine the effect that nandrolone has on Total Testosterone, E2, Prolactin, SHBG, free T, and DHT while taking TRT...

I know that most TRT places recommend 3-6 months for TRT to show results for low total T. My case may be different, as I have a test of 700 due to a high SHBG of 66. These were my baselines before starting Natesto. I’ve been on Natesto for 2 months, and I can’t really tell if it’s helping. I...

Gents, I’d love to get some input on this. I’ve started TRT 3 months ago. 43, fairly healthy, lifting 4 times a week. Baseline: BP 120/72 TT 275 (264-916) FT 12.5 (6.8-21.5) E2, SENSITIVE 10.6 (8-35) SHBG 25.7 (16.5-55.9) HCT 45.1 (37.5-51) TRIGLYCERIDES 117 (0-149) HDL 35 (39- ?) LDL...

I know there are many low SHBG posts and most are negative for the most part. I wanted to share some things that I have learned through some experimentation over the last 4 years seeking more libido that have helped me dial some things in to my current protocol: 19mg T-Proprionate ED .25mg AI...

Some threads state some folks "aromatize a lot" or "aromatize a little". What does this mean? Is it related to SHBG?

Hi everyone, I’m thinking of giving the scrotal cream a try after almost a year of injections and limited success with varying protocols. I’m wondering if there are any high shbg guys like myself that have tried the cream and what has been your experience? My shbg pre-trt was between 55-70. On...

I have been on TRT for 2.5 years and have had textbook levels - TT around 1000, FT in the 20's, SHBG fluctuates between 45-50 and E2 typically matches SHBG. I have never had any E2 symptoms though I will admit that my regimen would create an E2 nightmare for most - test cyp 60 mg every 3.5, HCG...

I haven't seen this mentioned previously. This suggests that those who are struggling with low SHBG should test for hyperinsulineamia. The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss. As SHBG is not known to alter the...