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  1. R

    What does low shbg actually mean ?

    So I don’t want the medical technical Mumbo jumbo about it’s a carrier protein and all but what I want to know is if someone has low shbg what do they feel like . Should they feel tired , not optimized , workouts suck ,low sex drive, recovery ect . Does having normal levels make you feel better ?
  2. Charliebizz

    Shbg/free t?

    I have a weird question I do t know if I'm going to be able to word it right. But I'm curious why free testosterone is so import if shbg transports androgens to the cellular targets. This paragraph is from a study on pub med. I can be completely off on my interpretation. classical hormones...
  3. T

    Low SHBG = lower dosed, more frequent injections. Why?

    It doesn't make sense to me, but I am sure there's something I'm missing. Note, I know that there is a complex relationship here, but I'm looking at this on the surface level. Isn't the "low SHBG = more frequent injection at a lower dose" protocol a bit counterintuitive? For example. Let's...
  4. D

    Ambiguous blood serum levels. Something else needs to be looked at?

    Maybe someone here can advise me on where and how to proceed next. Perhaps there is some obscure hormone level or something else that the doctors have neglected to test for that would unlock the mystery of my condition. I am in despair that I will ever get an answer, much less any treatment. I...
  5. M

    Advice/help for high shbg guy

    Any guys here with normal total t and high shbg (pre trt) that could give me some advice please? Had blood tests done 4 time over the last year. Each time everything was right where it needed to be axcpet for my shbg. Total t has been 620-743. Shbg has been 56-75. Putting my free t between 9.1...
  6. Nocalves

    SHBG vs estrogen

    If there is some ideal T/E2 ratio, what role does SHBG have there? I have extremely low SHBG, so should I reduce or increase ratio, because of different binding affinity.
  7. E

    Switch to IM from SQ? Lower E2? Sleep, digestion, maybe lower Free T...

    Long-term TRT patient, current protocol is 154mg/week in EOD SubQ shots (into thigh, belly, hip, etc). I've struggled on and off with digestion issues (constipation) and lack of deep sleep. A few months ago I started intermittent fasting and it's been good for dropping some weight. That combined...
  8. madman

    SHBG: biomarker and hepatokine?

    Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study have provided new insights at the population level. A thorough study of...
  9. D

    Scrotal Testosterone Cream

    Hey guys, It seems like this has been a great method to increase libido for many of the members and in particular DHT levels. For those where it has worked when you have introduced cream with normal injections is there a protocol that you found worked best or a cream dosage that was sufficient...
  10. T

    enclomiphene - shbg levels

    I've tried to see effects of enclomiphene on SHBG levels. Seen a study but lost the link for it. I think it was a study done as part of FDA approval. I've also seen a few different people posting before and after blood test results in a few different forums. It's starting to seem that maybe if...
  11. A

    Can trt crash shbg?

    My current protocol is 30mg Test Cyp eod. Before trt, my shbg was in the 80s n/mol. With every blood test over the past year it has gotten progressively lower 45 n/mol, 35, and now my most recent is 29. Im getting concerned that it might get TOO low (sub 20). Anyone have experience with this...
  12. Charliebizz

    How many low shbg guys use A. I

    What's up guys. I'm wondering how many low shbg guys use an a.i. I've never felt 100% dialed in on trt and have been at this on and off for over 10 years. I feel decent on 90mg of test e a week split mwf. I've tried many different frequency and doses and this has me feeling ok with tt of 500...
  13. S

    Does variation in peak/trough equate to libido?

    I have been on TRT for about three years. In January I switched to daily injections in an effort to control hematocrit, acne and sleep issues. I began at 20 mg per day and have slowly decreased my dose down to what is now 14 mg per day under the theory that the lowest possible dose is best. I...
  14. D

    SHBG Effect on TT, FT and DHT

    Hey guys, I am going to be trying NDT in the near future to increase my low thyroid numbers and am hoping a side effect may be increased SHBG from what other members have experienced. That said my TT is 1100, FT 29 and DHT 60. Right now my SHBG sits around 16. Say it increases to 30 what kind...
  15. P

    Shbg 25 nmol/litre

    Is 25 nmol litre considered low?
  16. D

    So many post on low Shbg, what range is low shbg?

    New to the forum and very new to trt (only 10 days in). I've had 4 tests pre trt over 18m and all with shbg with following results: 23 (latest and lowest) , 26, 31, 34 nmol/L. Should I be worried about having low shbg? Currently my protocol is e5d 125mg Sustanon. Do I need to move to EoD or...
  17. P

    Injection frequency effect on shbg

    Hi everyone ,I « heard »different thought about the effect of injection frequency on shbg For the same dose ,let’s say 200 mg. Injecting everyday instead of once a week for example will it increase or decrease shbg?
  18. A

    Will a 20mg bump decrease SHBG?

    I’m currently injecting 80mg once a week but I’m increasing my dose to 100mg. My current SHBG is 23 but I’m concerned this increase will lower it? What do you guys think?
  19. D

    DHEA Supplementation Effect SHBG?

    Hey guys, I recently began supplementing with a low dosage of micronized DHEA(10mg daily) to see if I can boost my lower levels. I ran 25mg a day at one point in the past with a cheap version and it caused some estrogen related side effects which I was trying to avoid with a better quality...
  20. J

    Full lab results (update)

    Thanks for taking the time. This is a follow up to my thread from last week (Total T > 1000 ng/dl (very high), Free T < 65 pg/ml (very low)). Total and Free same deal as last time, and not surprisingly SHBG is super high. Is there anything else in there I should pay attention to? I'm 40yo, in...
  21. M

    New bloods

    VA didn't have a Dr for me at local clinic, result I got a bunch of test done! I was really struggling with a T dose of 200mg split daily and in anticipation of new bloods I lowered dose to 150mg a week for one week and then to 140mg a week, a game I have to play so VA wont cut my dose. However...
  22. K

    Injection frequency & SHBG levels

    Hey TRT fellows, I’m still struggling to get the best out of my trt journey and have a question that I can’t seem to find a definitive answer for: Is a SHBG of 24.2 nmol/L considered low ? And Would u go with an ED or EOD protocol with a SHBG level similar to mine ? Thank you
  23. M

    boron for SHBG

    Has anyone been successful in decreasing SHBG level by using boron supplement without TRT?if YES, please give details
  24. A

    Minimum Dosage or freq for low SHBG

    Hi Everyone, I was wondering if anyone were able to decrease or stop the aromatization of testosterone without the use of AI. If yes, what would be the minimum dosage we need? Does daily injection reduces aromatization? Its hard to find proper dosage for people with low SHBG and they end up...
  25. B

    Interesting findings regarding my low SHBG after adding NDT when reviewing old labs....

    From my many posts on this forum many people probably know by now that I am a Low SHBG guy (8-18 labcrop range) which manifested after starting TRT 10 yrs ago... I have never gotten dialed in despite numerous changes in Test dosage, injections, etc... It's been a struggle to lose weight despite...
  26. B

    TRT induced Low SHBG and TRT dosage?

    Ok, I just read through the entire Low SHBG sticky thread and have been researching all over this forum regarding low SHBG and Trt dosing... I was able to pull a lab test from 12 years ago prior to starting TRT and I had a SHBG of 44 (lab corp range)... Since starting TRT my SHBG has dropped...
  27. B

    Novel insights in SHBG regulation and clinical implications

    Sex hormone-binding globulin (SHBG) is produced and secreted by the liver into the bloodstream where it binds sex steroids and regulates their bioavailability. Traditionally, body mass index (BMI) was thought to be the major determinant of SHBG concentrations and hyperinsulinemia the main cause...
  28. S

    What could cause decreasing TT on increasing T doses?

    I've had an issue for the last couple of months now where my TT has not been nearly as high as it used to be given a particular dose of T cyp. Early Feb I saw a 600 off 150mg/week. Last week, 730 off of 182mg/week + 150IU HCG EOD. Last fall, I was at 1200 with 200mg/week. Where the hell could...
  29. D

    Nandrolone (Deca Durabolin): Effect on Lab Tests

    PARTICIPATION NEEDED! Of those EM members that have taken nandrolone or are currently taking nandrolone alongside their TRT, we are conducting a small ExcelMale study to help determine the effect that nandrolone has on Total Testosterone, E2, Prolactin, SHBG, free T, and DHT while taking TRT...
  30. V

    How long for TRT to reduce high SHBG?

    I know that most TRT places recommend 3-6 months for TRT to show results for low total T. My case may be different, as I have a test of 700 due to a high SHBG of 66. These were my baselines before starting Natesto. I’ve been on Natesto for 2 months, and I can’t really tell if it’s helping. I...
  31. T

    Low SHBG, Strength, EOD, etc

    Gents, I’d love to get some input on this. I’ve started TRT 3 months ago. 43, fairly healthy, lifting 4 times a week. Baseline: BP 120/72 TT 275 (264-916) FT 12.5 (6.8-21.5) E2, SENSITIVE 10.6 (8-35) SHBG 25.7 (16.5-55.9) HCT 45.1 (37.5-51) TRIGLYCERIDES 117 (0-149) HDL 35 (39- ?) LDL...
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