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  1. RP McMurphy

    First Lab Post! “Should I stay or should I go?”...would appreciate some guidance. Thank you!

    I’m a 45 yo male, 150 lbs. Prior to starting any testosterone therapy my labs in January 2018 were in range (Total T 601 280-1100ng/dl, Free T 10.43 1.9-27ng/dl), but I wanted to see if increasing testosterone levels would help to improve fatigue. I always had a high sex drive, with decent...
  2. Nelson Vergel

    Pregnenolone Decreases Veterans' Chronic Back Pain More than Placebo

    Use of pregnenolone resulted in a significant reduction in pain intensity rating in veterans with chronic low back pain after 4 weeks of treatment, findings of a recent randomized, double-blind, placebo-controlled clinical trial showed. Jennifer Naylor, PhD, and a team of North Carolina-based...
  3. Gianluca

    Pregnenolone Cream scrotum feedback

    I would like to hear any experiences, in applying Pregnenolone cream on the scrotum vs other body parts, did the scrotum application improve your anxiety better?calmness? thanks
  4. S

    Help determining proper pregnenolone dosage and frequency

    Hi all, I've been experimenting with pregnenolone for over a year now, with varied success. I seem to get benefits at 100mg (such as higher libido, more pronounced nighttime erections and better sleep); however, I don't get these results consistently. If I try to continue 100mg daily, the...
  5. F

    Raising Pregnenolone, Progesterone and DHEA with HCG

    1. Anyone who has had low Pregnenolone and/or DHEA how much did adding HCG raise your levels? Both my pregnenolone and DHEA levels are below the minimum range. And I felt like shit on testosterone only. I have recently added HCG to my protocol and want to know if anyone has seen their levels...
  6. Z

    Pregnenolone makes high dose Testosterone tolerable

    Skip to 2:00 Dave Lee explains that a Pregnenolone deficiency doesn't allow for higher testosterone dosages to be tolerated. Supplementing Pregnenolone is an easy fix instead of lowering your testosterone levels.
  7. D

    Serious Low E2 Symptoms. Could Progesterone be the cause? How to lower it?

    Hello, has anyone ever used Pregnenolone with a too high dose and had side effects which could stem from high progesterone? If yes, and you stopped using it, how long till you felt better? Is there a way to lower Progesterone,. as I believe it either lowers my e2 or blocks it from binding to...
  8. Nelson Vergel

    Pregnenolone and Progesterone for Men: Pharmacokinetics and Studies

    "Pregnenolone can be administered orally, subcutaneously, intravenously, intranasally, and topically/transdermally. Oral pregnenolone has high metabolism and low bioavailability.28 It is lipophilic and readily crosses the blood brain barrier. There is very limited data on the pharmacokinetics...
  9. Hormetheus

    Adrenal fatigue: The best methods to increase cortisol naturally

    Hey, I am a final year medical student. For years I had life-impairing fatigue due to low-cortisol issues. After doing a LOT of research, I collected a list of methods we can try to raise our cortisol naturally and therefore to help get rid of HPA-dysfunction. I share this here because I am...
  10. Gianluca

    Pregnenolone Cream Vs Capsule on downstream metabolites?

    is there any difference for Pregnenolone bypassing the liver on downstream metabolites? is there less conversion to Progesterone? I heard once Dr John Crisler, mentioning how oral pregnenolone may be better for people with anxiety, because it gets converted more into allopregnenolone with the...
  11. W

    Pregnenolone prevents testicular atrophy In that thread they say a ratio of 10:1 pregnenolone to testosterone daily (i.e. 100mg preg for 10mg testosterone) keeps your nuts from shrinking. Is this BS? First I've heard of that.
  12. T

    Pregnenolone & DHEA, any of you guys taking them and seeing benefits?

    I have a bottle of 100mg pregnenolone tablets at home and took the first one this morning. Other than that I've no experience with it myself.
  13. T

    HCG Pros and Cons while on TRT

    I have been on TRT for 6 weeks now... feeling pretty good... my Free T went from 5.2 to 27... Doc thinks that is a little high, so recommended reducing weekly dose... but pretty happy and hoping to feel even better after a few more weeks... I read many things about HCG... good and bad... I'd...
  14. G

    Pregnenolone, missing piece?

    Just wondering if pregnenolone has been the missing puzzle piece in anyone’s protocol, and if things finally clicked when they added it. Thanks.
  15. T

    Pregnenolone and boron as alternatives to TRT?

    I've been having some problems with side effects after 4 weeks of 100mg/wk Test-Cyp... and no noticeable benefits. I am considering stopping, and trying Pregnenolone 5mg/day and boron 10mg/day after allowing time for the T to clear out of my system... maybe add 20mg zinc picolonate... any...
  16. S

    New User, Looking for advice, Questions about HCG, Thyroid, DHEA, etc.

    At age 33, After years of depression, anxiety, fatigue, weight gain, sleep problems, ed, etc. I convinced my doctor to test my hormones. I was specifically interested in my Cortisol levels due to prolonged profound amounts of physical anxiety. The results of what he tested were; Total...
  17. C

    Pregnenolone kills libido

    Hello, anyone else here whos libido goes down with pregnenolone? I use 50mg day and its totally kills my libido and erection, it took a while to figure it out. Same thing happened with even smallest dosage 500iu/wk hcg in a past. Probably im sensitive to increased progesterone from pregnenolone...
  18. P

    HPTA Recovery Log to Re Start Testosterone Production

    Hello everyone. Following my failed attempt at restarting my natural testosterone production, I'm back on HRT in the form of 500iu HCG 3x p/w. ---------------------------------------------------------------------------------- Current issues: Always cold, especially extremities Absent Libido...
  19. P

    Progesterone Levels on TRT

    I’ve seen various accounts of men on TRT with deficient levels of progesterone -- many of whom had normal levels prior to treatment. LH is important for leydig cholesterol -> pregnenolone conversion, and also for adrenal steroidogenesis. HPTA suppression and the subsequent absence of LH is...
  20. X

    Starting Over on TRT, A Few Questions about Free T, DHT, DHEA...

    Hi everyone, I would appreciate some input on a few questions: 1) The Tru T Calculator is something new to me that I've only seen since joining this site. What is the range used for free t here? I was on a protocol where I was taking 40mg every third day. This put my total T at 680. My...
  21. S

    Still trying to get pregnenolone to work - advice welcome

    I tried pregnenolone about a month ago based solely on the many positive reviews from others and across the internet. I was absolutely stunned by it, for about a week, after which I started getting really easily angered, and unable to sleep. I stopped for a few days, tried again at a lower dose...
  22. Maca

    High Pregnenolone - NOT SUPPLEMENTING??

    Hey! I recently got my Pregnenolone tested and I came back what I think is very high. I am not taking any pregnenolone just testosterone. I suffer with brain fog and fatigue still after starting TRT and wonder if this has something to do with it. Any thoughts would be great as I can't find...
  23. G

    Considering Pregnenolone

    I’m back to considering pregnenolone since my levels are way below bottom of the range and maybe that’s the source of my sleep issues. I already have low normal cortisol levels, and so my concern is if I respond poorly, could it shutdown natural production of cortisol enough to cause real...
  24. S

    Trouble with first day on pregnenolone

    I tried 30mg pregnenolone this morning with breakfast, and about 2 hours later, was hit with such fatigue, I almost had to leave work. It was truly unbearable. Also had some dandelion tea, and I thought that might have been it - but I made some more and it doesn't seem to be the cause. Writing...
  25. G

    Pregnenolone question

    If I have natural DHEA-S levels at the top end of the range, sometimes slightly over, is it physiologically impossible for my pregnenolone levels to be low? DHEA can only be made from pregnenolone, correct? So in order for my DHEA to be high, I must have good levels of pregnenolone, right? What...
  26. D

    Pregnenalone and TRT

    Is anyone taking Pregnenalone as part of the TRT protocol? do you mind sharing your experience with it? how long have you used it? were you levels low prior to starting supplementing it? what is your dose and how often? are you using capsules or in compounded cream? which one is best
  27. J

    Pregnenolone and DHEA for the non-TRT male

    I'm 61, and am not on TRT...yet. Would it be smart to have these other 2 hormones tested since they decline with age?
  28. W

    OTC Pregnenolone or Pregnenolone through Defy?

    I've been using Douglas Laboratories brand Preg with great results for months now. 25mg in the morning and 25mg again in the late afternoon. This last week I started taking two pills in the morning instead. To see how I felt with a larger single dose. I like it more. As I was surfing around on...
  29. L

    Who doesn't supplement DHEA and Pregnenolone despite labs showing your low?

    I wonder if anybody doesn't take dhea and preg while on trt despite being low on labs?
  30. G

    If I can't afford HCG, is supplementing with Preg/DHEA the next best option?

    I've been reading lots of information out there on "backfilling pathways" and how supplementing Pregnenolone and DHEA is good in order to supply some of the missing components that TRT will suppress. I am still weighing my options but its looking like HCG may be cost prohibitive at least at this...
  31. G

    How many of you take pregnenolone

    Just trying to get a ball park figure of how many men here use pregnenolone in their protocol.
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