Zinc vs anastrozole

Many of us were able to eliminate an AI by going to small daily or EOD Test doses instead of twice weekly or weekly doses.
 
ERO said it - you have an excellent chance of lowering E2 by more frequent, smaller injections. If that doesn't work, I wouldn't expect zinc to really impact your estradiol in a meaningful way. If it did, wouldn't everyone who needed an AI be using it?
 
Very valid point on zinc coasterwatcher. So when doing every other day is 50 mg about right considering I'm doing 100 mg every 3.5 now? That keeps my right around 1100 to 1200 with free testosterone right around 30 on the of 9-26.
 
ERO said it - you have an excellent chance of lowering E2 by more frequent, smaller injections. If that doesn't work, I wouldn't expect zinc to really impact your estradiol in a meaningful way. If it did, wouldn't everyone who needed an AI be using it?

I concur. I just got my labs back (will post later tonight), and my sensitive E2 shot up to 68. I pin Test every 3.5 days, and take a zinc supplement daily. I have a follow up with Dr. Crisler in about 2 weeks, so we'll be discussing options...maybe an EOD schedule for Test, or a tiny dose of AI to help reign in my E2. Will discuss this later when I have more time. At the airport now...gotta go!!
 
Very valid point on zinc coasterwatcher. So when doing every other day is 50 mg about right considering I'm doing 100 mg every 3.5 now? That keeps my right around 1100 to 1200 with free testosterone right around 30 on the of 9-26.

What is your estradiol level? Was it measured with the appropriate test (LC, MS/MS)?
 
I take 50mg zinc daily and take AI on an infrequent basis as needed when I feel symptoms of elevated E2. When I do take the AI its only .25mg maybe once or twice a week at most. I feel better with slightly elevated E, but thats just me. I used to try to manage e2 with just zinc and chrysin but it really had no effect on keeping it in check
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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