Would this likely be low or high E2?

hankerata

New Member
I am experiencing some symptoms that I suspect are related to high E2 -- but I also wonder if low E2 could be the cause. I'd appreciate any thoughts from the hivemind here.

Current regiment: T Cyp 200 mg/ml and HCG 400 iu -- both twice weekly. Also take .25 Anastrozole twice weekly, taken at time of T and HCG shots.

During my last blood work about five months ago, my E2 was elevated: 45.1 (reference range: 8-35). We slightly increased my T at that time, from 150 to 200, but doubled my Anastrozole from .125 to .25 twice weekly.

The current regiment had been great for about five months. My blood pressure and cholesterol have all gone down to normal ranges since starting TRT. And my intermittent ED issues were resolved since starting TRT and taking the occasional Cialis.

This past week, I've struggled with sex: slow start requiring a lot of manual stim before intercourse, lost erection during intercourse once, almost lost it another time. At the same time, I've noticed that I am kinda sweaty and clammy just before going to bed. (No nipple sensitivity -- which I generally do not get at any level -- and my weight is not elevated.)

Doc suggested upping my Anastrozole again slightly if I notice any high E2 symptoms. Would it be fair to say this is most likely related to high E2? My only concern, and I reason it's an outside concern, is that it could be low E2 -- and so increasing Anastrozole will just make this worse.

I am due for a full blood workup in about six weeks, so I'll get some definitive answers then. But curious what others think -- and whether these symptoms would suggest a need to slightly increasing Anastrozole. Thanks!
 
I think that throwing more drugs at it without the proper testing would not be the route that you want to go down and so what it's been "off" in the last week...no reason to up a dose, of anything, because of that. The 5 months by your own words have been great.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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