Will discontinued use of aromatase inhibitor reduce testosterone?

bluerage

Member
My friend had been using AAS for 20 years before he went cold turkey at 29. From my understanding he never really cycled off. He's now 32 and his natural testosterone levels never recovered and has been prescribed testosterone, HCG and an aromatase inhibitor from a men's health clinic.
His TT is 32.6 nmol/L (lab range is 8.4-28.8) and his FT sits at 1004 pmol/L (lab range is 196-636). He did not test his SHBG but I would assume it's on the lower end. His estradiol test is unreliable since it was not the sensitive assay.
What I'm concerned with is his RBC which came in at 6.33 xE12/L (4.5-6.0). I don't know if this is high enough to stress the heart but I suggested he try giving blood. Unfortunately he was born in Europe and he is unable to give blood here in Canada because of the mad cow disease outbreak.
He doesn't want to lower his T dose of 100mg/week. If he were to discontinue the AI would he see a lowering of his TT and FT? Would this be enough to lower his RBC?
 
My friend had been using AAS for 20 years before he went cold turkey at 29. From my understanding he never really cycled off. He's now 32 and his natural testosterone levels never recovered and has been prescribed testosterone, HCG and an aromatase inhibitor from a men's health clinic.
His TT is 32.6 nmol/L (lab range is 8.4-28.8) and his FT sits at 1004 pmol/L (lab range is 196-636). He did not test his SHBG but I would assume it's on the lower end. His estradiol test is unreliable since it was not the sensitive assay.
What I'm concerned with is his RBC which came in at 6.33 xE12/L (4.5-6.0). I don't know if this is high enough to stress the heart but I suggested he try giving blood. Unfortunately he was born in Europe and he is unable to give blood here in Canada because of the mad cow disease outbreak.
He doesn't want to lower his T dose of 100mg/week. If he were to discontinue the AI would he see a lowering of his TT and FT? Would this be enough to lower his RBC?
Chronic low E2 (caused by long term use of an AI) will cause cardiovascular issues up to and including heart attack. Disontinuing his AI will not lower his Testosterone. If he has the option to get blood work done more often, (you also don't say how much on an AI he's using) I'd Titrate the AI dose down every few weeks based on his E2 levels. He doesn't want Estadiol too low. Slightly higher is better, but his goal
should be to get his E2 into mid-range of Normal.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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