Why Testosterone Decline Is the New Health Epidemic

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Shalin Shah is the CEO of Marius Pharmaceuticals and a leader in metabolic and men’s health. He spearheaded the FDA approval of the first oral testosterone therapy for men with low testosterone. With a mission to make hormone health more accessible, Shalin advocates for education, innovation, and redefining testosterone therapy as a foundation for longevity and quality of life.




What We Talk About:


  • Why testosterone levels are rapidly declining in both men and women.
  • The connection between low testosterone, obesity, and chronic metabolic disease.
  • How environmental toxins, plastics, and fragrances disrupt hormones.
  • The symptoms and early warning signs of testosterone deficiency.
  • Why younger men are now showing record-low testosterone levels.
  • What to test for: total vs. free testosterone, SHBG, LH, FSH, and estradiol.
  • The problem with “normal” lab ranges and how they’ve shifted over time.
  • Comparing injections, gels, pellets, and oral testosterone therapy.
  • Why oral testosterone is changing the future of hormone replacement.
  • The safety differences between delivery methods and how to minimize side effects.
  • Myths about testosterone and heart disease, cardiovascular risk, and prostate cancer.
  • How testosterone impacts mood, energy, metabolism, and longevity.
  • The fertility question: how TRT affects sperm count and new studies addressing it.
  • Why testing testosterone should be part of standard preventive care.
  • The future of hormone optimization for women and the FDA’s changing approach.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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