Why Gleason 6 Prostate Cancer is Not Cancer

madman

Super Moderator

In this insightful episode of our podcast, we delve into a controversial and highly relevant topic in the realm of prostate cancer – the classification and implications of Gleason 6 prostate cancer. Our guest, Dr. Scott Eggener, a renowned co-director of the U Chicago Medicine High Risk and Advanced Prostate Cancer Clinic Program, brings his extensive research and expertise to the table. With over 250 publications, Dr. Eggerner has been a leading voice in questioning the traditional labeling of Gleason 6 as cancer, given its non-life-threatening nature and distinct pathological appearance.

This episode offers a deep dive into the reasons behind Dr. Eggerner’s argument for not classifying Gleason 6 as cancer, contrasting his views with those of Dr. Adam Kiebel, who advocates for its recognition as cancer. We explore how the term 'cancer' carries significant emotional and psychological weight, often leading to anxiety, depression, and instability among patients.

Join us for a compelling discussion with Dr. Scott Eggener from the University of Chicago as we navigate the complexities of prostate cancer classification and its impact on patient care and perception. This episode promises to be a thought-provoking exploration of a topic that affects many yet needs to be discussed with depth and clarity.


Chapters


00:00 Why Gleason 6 Prostate Cancer is Not Cancer with Dr Scott Eggener
00:05 Risk Stratification Process with Gleason Six
00:11 The Role of Genomic Testing in Gleason Six
01:23 The Impact of High-Risk Genomic Test Results
01:47 The Importance of Data in Decision Making
02:07 The Role of Genetic Testing in Risk Stratification
02:13 The Importance of Regular Follow-ups
03:15 The Value of Free PSA in Risk Stratification
04:22 Understanding Free PSA
05:03 The Importance of Free PSA in Predicting Outcomes
08:02 The Role of Biomarkers in Risk Stratification
09:55 The Impact of Different Risk Stratification Approaches
11:56 The Challenges of Decision-Making in Prostate Cancer Treatment
13:32 Conclusion: The Bright Outlook for Early-Stage Prostate Cancer
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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