Where to find dosage and cycle time?

[LotsOfQuestions]

Searching and finding a wide range of dosages for items like TB-500 that range from 20 mcg to 1,000 mcg per day.
Finding large ranges for other peptides as well.
Which web site are you using to calculate the dosage?

 

[BigTex]

There is a good reason doses vary. Due to the lack of published research on TB-500, there are currently no specific dosage recommendations for research purposes. Now back to the real world.....people in the trenches have found different amounts work. Of course we are all different and what works on you may not work on me at the same dose. So in the trench dosages vary greatly.

1. Ruff, D., Crockford, D., Girardi, G., & Zhang, Y. (2010). A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Annals of the New York Academy of Sciences, 1194, 223–229. https://doi.org/10.1111/j.1749-6632.2010.05474.x

https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2010.05474.x

1. Wang, X., Liu, L., Qi, L., Lei, C., Li, P., Wang, Y., Liu, C., Bai, H., Han, C., Sun, Y., & Liu, J. (2021). A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin β4 in healthy Chinese volunteers. Journal of cellular and molecular medicine, 25(17), 8222–8228. https://doi.org/10.1111/jcmm.16693

https://onlinelibrary.wiley.com/doi/10.1111/jcmm.16693

In 1st study 2mg/wk were administered as a dose/wk, which is about 285mcg/d for 14 days. Will this work for everyone? We just don't know much more that what these two studies tell us. Now the 2st study used ascending doses of either 42, 140, 420, or 1260 mg daily for 14 days. Both studies dealt with promoting myocardial cell survival during acute myocardial infarction. All other research has been done on animals. It has been used frequent and to this day to treat race horses. I can tell you that the guys who own these very expensive horses continue to use TB 500 because it gives results. It is also banned by WADA because athletes are using it with success. So anecdotally, this peptide seems to work. The dose still varies. I just got through using 2mg 2x/wk with some success treating osteoarthritis pain.

Here is what I have always recommended with TB500:

1. 6-10mg per week (0.84459mg/kg) or 850mcg/1400mcg/d for the 1st 4 weeks​

2. 2mg per week or 285mcg/d for 2-6 months or until fully healed​

As you see there is a wide range in the beginning of the treatment depending on how it works for you. At week 5 and beyond you cut the dose

As far as most other peptides, saturation doses are usually figured at 100mcg or 1mcg/kg. This simply means that ~100mcg will saturate the receptors fully. So doing more is not really going to give benefits and as you increase the dose unwanted side effects start increasing in a dose response relationship. The biggest reason you don't see dosing on peptide sites is because it is against the law.

 

[LotsOfQuestions]

Thanks for the reply.
I have been doing about 1,000mcg daily for about 26 days.
Going to 2mg seems like a big drop for months 2-6. Is this common for all Peptides or just TB500?

Also, is there any benefit to doing 2mg per week via 1-2 injections as opposed to daily?

 

[BigTex]

Everyone responds differently. I have had some mild pec tears with minimal bruising and healed the damage in two weeks. I was going 500mcg/day BPC 157 and micro-injected directly into the injury. I actually did a square around the injury and injected into each corner and the remaining into the center. I think more gets absorbed locally that way but eventually it all goes systemic.