What to do if Lipodystrophy is suspected?

DarkMan X

Member
Hi,

My name is Gabe. I've been on TRT since August 2021. I've switched to Defy Med in March of 2022. I am also Type 2 diabetic who uses Novolog Subcutaneous insulin.

Since Defy is the only clinic that suggested using Testosterone Subcutaneously, I did so starting in March 2022. However, I've also noticed (since March) that my SubQ insulin is not as effective as before. Diabetics are often warned of a condition called "Lipodystrophy" which happens after some places on your body get used too much for drug injections. Lipodystrophy can also cause your body to "reject" the given injected medication.

Has anyone here ever had this happen to them before? When your perform a Subcutaneous injection (in any place on your body) and the given medication (insulin, HcG, testosterone, ANYTHING) just doesn't work or just doesn't absorb at all? And if so - what did you do to fix this condition?

Thanks for reading!
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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