What is the testosterone dose for muscle gain?

Some of the guys I work out with know that i inject T. It has come up why then do I not put on more gains, I do heavy rssitance training and little cardio. I explained that I am on a theraputic dose. Shoot I take a paltry 30 mg twice a week to keep red blood cells in line, so i could never do the super dosing that alot of body builders do.
At what levels do you begin to see substantial mass gains in the gym? I thought i read where guys may use 1500 mg/ injection when cycling on. I would die of a stroke in a matter of weeks doing that heavy dosage!!!

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The Bhasin Testosterone Dose-Response Study: What 125mg Weekly Teaches Us About Optimal TRT Dosing
By Nelson Vergel | ExcelMale.com | Updated December 2025
In the world of testosterone replacement therapy, one question comes up more than any other: "What's the right dose?" The answer isn't as simple as a single number, but a landmark 2001 study by Dr. Shalender Bhasin and colleagues provides the most rigorous dose-response data we have—and its findings remain remarkably relevant for optimizing TRT protocols today.
Published in the American Journal of Physiology: Endocrinology and Metabolism, this study systematically tested five different testosterone doses in healthy young men, measuring everything from muscle mass and strength to body fat, sexual function, and safety parameters. The results established that 125mg per week of testosterone enanthate represents a critical threshold—the lowest dose that produces statistically significant improvements in body composition while maintaining testosterone levels in the high-normal range with minimal adverse effects.
This article provides a comprehensive analysis of the Bhasin study and explains how its findings can inform modern TRT dosing decisions.

Study Design: The Gold Standard for Testosterone Dose-Response Research​

What makes the Bhasin study exceptionally valuable is its rigorous methodology. Unlike typical TRT studies that simply compare testosterone to placebo, this study created five distinct hormonal environments by suppressing each participant's endogenous testosterone production and then replacing it at precisely controlled doses.

Participants and Protocol​

Participants: 61 healthy eugonadal men aged 18-35 years with normal baseline testosterone levels and prior weight-lifting experience. This ensured the study measured testosterone's effects independent of training adaptation.
Hormonal Suppression: All participants received monthly injections of a long-acting GnRH agonist, which completely suppressed their endogenous testosterone production. This "chemical castration" created a clean slate—ensuring that all circulating testosterone came from the administered injections rather than natural production.
Testosterone Doses: Men were randomized to receive weekly intramuscular injections of testosterone enanthate at one of five doses: 25mg, 50mg, 125mg, 300mg, or 600mg per week for 20 weeks.
Standardized Conditions: Energy and protein intakes were standardized across all groups, eliminating dietary variation as a confounding factor. This is crucial—many studies fail to control for nutrition, making it impossible to isolate testosterone's effects from dietary differences.

Resulting Testosterone Levels by Dose​

The study measured nadir (trough) testosterone levels—the lowest point in the week, typically occurring just before the next injection. These trough values are clinically important because they represent the minimum testosterone exposure:

Weekly Dosee
Mean Nadir T (ng/dL) Lower Concentration
Hormonal Status
Clinical Range
25 mg
253

Severely hypogonadal

Below range

50 mg

306

Low-normal

Low end of range

125 mg

542

High-normal

Mid-to-upper range

300 mg

1,345

Supraphysiological

Above range

600 mg

2,370

Highly supraphysiological

Steroid-cycle range
Key Insight: The 125mg dose produced trough testosterone levels of 542 ng/dL—solidly in the high-normal range for healthy young men. This is clinically significant because many TRT practitioners aim for trough levels in the 500-700 ng/dL range, suggesting that 125mg weekly represents an evidence-based starting point for physiological testosterone replacement.

Body Composition Results: The 125mg Threshold Effect​

Perhaps the study's most clinically relevant finding was the identification of a clear threshold effect for body composition changes. Not all doses produced equivalent benefits—and statistical significance only emerged at 125mg and above.

Fat-Free Mass (Lean Body Mass) Changes​


Weekly Dose
Fat-Free Mass Change
Fat Mass Change
Statistical Significance
25 mg
No significant change

Increased

No

50 mg

No significant change

No change

No

125 mg

+3.4 kg (7.5 lbs)

Decreased

Yes (P<0.05)

300 mg

+5.2 kg (11.5 lbs)

Decreased

Yes (P<0.05)

600 mg

+7.9 kg (17.4 lbs)

Decreased

Yes (P<0.05)
The changes in fat-free mass were highly dose-dependent (P = 0.0001) and strongly correlated with log testosterone concentrations (r = 0.73, P = 0.0001). This linear dose-response relationship demonstrates that testosterone's anabolic effects on muscle are predictable and directly proportional to circulating hormone levels—more testosterone equals more muscle, at least within the range studied.
The Clinical Takeaway: Men receiving 25mg or 50mg weekly—resulting in low or low-normal testosterone levels—did not experience statistically significant improvements in lean mass. The 125mg dose was the minimum effective dose for producing meaningful body composition changes.

Strength and Power: Functional Outcomes Follow the Same Pattern​

Body composition changes are only meaningful if they translate to functional improvements. The Bhasin study measured leg press strength (one-repetition maximum), leg power (Nottingham power rig), and muscle volumes (MRI-measured thigh and quadriceps).
All three parameters showed the same dose-dependent pattern as fat-free mass:
• Leg Press Strength: Positively correlated with testosterone dose; significant improvements at 125mg and above
• Leg Power: Positively correlated with testosterone dose; demonstrates that muscle quality—not just size—improved
• Thigh Muscle Volume: MRI confirmed that testosterone-induced lean mass gains represented true muscle hypertrophy, not water retention
• Quadriceps Volume: Dose-dependent increases ranging from no change (25-50mg) to +48mL at 600mg
Companion studies using muscle biopsies from the same participants confirmed that the increase in muscle volume was due to true muscle fiber hypertrophy—increases in the cross-sectional area of both Type I (slow-twitch) and Type II (fast-twitch) muscle fibers—rather than intramuscular water or glycogen accumulation.

What Testosterone Did NOT Change: Sexual Function, Cognition, and PSA​

One of the study's most surprising findings was that several outcomes typically associated with testosterone did not show dose-dependent changes:

Sexual Function and Libido​

Sexual function questionnaires did not show significant changes at any dose—even at 600mg weekly. This may seem counterintuitive, but there are important caveats to consider:
1. Participants were young, healthy men with normal baseline testosterone and normal sexual function. There was no "floor" to improve from—they were already functioning optimally.
2. Sexual function may have a lower testosterone threshold than muscle anabolism. Once testosterone exceeds a minimum level (perhaps 250-350 ng/dL), additional testosterone may not further enhance libido or sexual performance.
3. Subsequent analysis suggested that doses of 300-600mg weekly showed a slight trend toward increased sexual desire—but this did not reach statistical significance given the small sample sizes.
Clinical Implication: Men with hypogonadism and sexual dysfunction may experience dramatic improvements with TRT because they are starting from deficient levels. But for men already in the normal range, higher doses may not translate to better sexual function.

Visual-Spatial Cognition and Mood​

Cognitive tests measuring visual-spatial abilities and mood assessments showed no significant changes across any dose group. Again, this likely reflects the normal baseline status of the participants rather than a true absence of testosterone effects on brain function.

PSA Levels​

Prostate-specific antigen (PSA) levels did not change significantly at any dose during the 20-week treatment period. This is reassuring for the safety profile of testosterone therapy in young men, though it should not be extrapolated to older men or longer treatment durations where age-related prostate changes may create a different context.

Safety Parameters: Where Higher Doses Show Tradeoffs​

While testosterone's anabolic benefits scaled linearly with dose, so did certain adverse effects. The study documented dose-dependent changes in several safety-relevant parameters:

Hemoglobin and Hematocrit​

Hemoglobin levels increased in a dose-dependent manner, with higher testosterone doses producing greater elevations. This reflects testosterone's stimulatory effect on erythropoiesis (red blood cell production). While modest increases in hemoglobin can be beneficial, excessive elevation (hematocrit >54%) increases blood viscosity and cardiovascular risk. The 125mg dose produced modest hemoglobin increases that remained within safe ranges for most participants.

HDL Cholesterol​

HDL ("good") cholesterol decreased in a dose-dependent manner—the higher the testosterone dose, the greater the HDL suppression. This is a recognized effect of androgens on hepatic lipid metabolism and represents a potential cardiovascular concern at supraphysiological doses. At 125mg weekly, HDL suppression was minimal and likely clinically insignificant. At 300-600mg weekly, HDL decreases were substantial and warrant consideration in risk-benefit analysis.

IGF-1 Levels​

Insulin-like growth factor 1 (IGF-1) levels increased with testosterone dose. IGF-1 is an anabolic hormone that contributes to muscle protein synthesis and may partially mediate testosterone's effects on muscle. However, chronically elevated IGF-1 has been associated with increased cancer risk in some epidemiological studies, adding another reason to favor physiological over supraphysiological dosing.

Why 125mg Represents the "Sweet Spot" for TRT​

The Bhasin study provides compelling evidence that 125mg of testosterone enanthate weekly represents an optimal balance between efficacy and safety for testosterone replacement therapy. Consider the following:
1. Testosterone Levels in the High-Normal Range: The 125mg dose produced nadir testosterone levels of 542 ng/dL, placing men in the upper-normal physiological range. This is consistent with levels seen in healthy young men and aligns with current clinical targets for TRT (500-700 ng/dL trough).
2. Statistically Significant Body Composition Benefits: Unlike lower doses, 125mg produced meaningful improvements in fat-free mass (+3.4 kg) and reductions in fat mass—benefits that matter for metabolic health, functional capacity, and quality of life.
3. Minimal Adverse Effects: At 125mg, increases in hemoglobin, decreases in HDL, and elevations in IGF-1 were modest and clinically manageable. The 2005 companion study in older men specifically identified 125mg as providing "the best trade-off... associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength."
4. The Threshold Effect: The data clearly show that 25mg and 50mg weekly are insufficient for producing anabolic benefits—these doses merely prevent severe hypogonadism without optimizing body composition. For men seeking the benefits of TRT, underdosing represents a missed opportunity.

Clinical Applications: Translating Research to Practice​

Starting Dose Recommendations​

Based on the Bhasin data, 100-125mg of testosterone cypionate or enanthate weekly represents a reasonable starting dose for most men initiating TRT. This dose:
• Achieves high-normal testosterone levels
• Produces statistically significant improvements in body composition
• Minimizes the risk of supraphysiological exposure and associated adverse effects
• Provides a baseline from which to adjust based on individual response

Individual Variability Requires Monitoring​

The study reports mean values, but individual responses varied considerably. Some men achieved much higher or lower testosterone levels than average at the same dose due to differences in absorption, metabolism, SHBG levels, and other factors. This underscores the importance of checking actual testosterone levels (ideally trough values) after initiating therapy and adjusting the dose to achieve target levels rather than treating based on a fixed dose.

Injection Frequency Considerations​

The Bhasin study used once-weekly injections. However, modern TRT practice increasingly favors twice-weekly or even more frequent injections to minimize peak-to-trough fluctuations and maintain more stable testosterone levels. A man receiving 125mg weekly could alternatively inject 62.5mg twice weekly or 40-42mg every other day, potentially achieving better symptom control with fewer side effects related to hormonal peaks and troughs.

Conclusion: The Enduring Relevance of the Bhasin Dose-Response Data​

More than two decades after publication, the Bhasin testosterone dose-response study remains the definitive reference for understanding how testosterone dose affects body composition, strength, and safety parameters. Its findings have stood the test of time and continue to inform evidence-based TRT practice.
The key takeaways for men considering or currently on TRT:
• 125mg weekly is the minimum dose for significant body composition benefits —lower doses may not produce meaningful improvements despite achieving "normal" testosterone levels
• More is not always better —supraphysiological doses (300-600mg weekly) produce greater muscle gains but at the cost of increased adverse effects
• Different outcomes have different dose-response curves —sexual function may plateau at lower doses than required for optimal body composition
• Individual monitoring is essential —actual testosterone levels matter more than the dose administered
For clinicians and patients seeking to optimize TRT outcomes while minimizing risks, the 125mg weekly dose (or its equivalent with other formulations and injection frequencies) represents a scientifically grounded starting point—the threshold at which testosterone replacement truly becomes testosterone optimization.

Related ExcelMale Forum Discussions​

Explore these community discussions for additional insights:
Responses of Different Doses of Testosterone Injections on Body Composition, Strength, etc. – Original thread with study summary and graphs
Effect of Low and High Doses of Testosterone Injections on Hematocrit, PSA and HDL – Deep dive into safety parameters at different doses
What is the Optimum TRT Dose for Muscle Growth? Nelson Vergel Reviews the Data – Video discussion of optimal dosing strategies
How to Predict Estradiol and DHT at Different Testosterone Doses – Predictive modeling for hormone metabolites
The 12-Year-Old Study That Proves Testosterone Injections Every Two Weeks Fail – Why injection frequency matters as much as dose
How Long Does Testosterone Take to Show Effects? – Timeline expectations for TRT benefits

Key References​

1. Bhasin S, Woodhouse L, Casaburi R, et al. Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab. 2001;281(6):E1172-E1181. [PubMed]
2. Bhasin S, Woodhouse L, Casaburi R, et al. Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab. 2005;90(2):678-688. [PubMed]
3. Sinha-Hikim I, Artaza J, Woodhouse L, et al. Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. Am J Physiol Endocrinol Metab. 2002;283(1):E154-E164. [PubMed]
4. Sinha-Hikim I, Cornford M, Gaytan H, et al. Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. J Clin Endocrinol Metab. 2006;91(8):3024-3033. [PubMed]
5. Pharmacology of testosterone replacement therapy preparations. Transl Androl Urol. 2016;5(6):834-843. [PMC Full Text]
6. Full text of original study. American Physiological Society. [Journal Full Text]
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Testosterone replacement therapy requires a prescription and should be supervised by a qualified healthcare provider. Individual responses to therapy vary, and treatment decisions should be made in consultation with your physician based on your specific clinical circumstances.


About ExcelMale.com: ExcelMale is a men's health forum with over 24,000 members and 20+ years of archived discussions on testosterone replacement therapy, hormone optimization, and sexual health. Founded by Nelson Vergel, author of Testosterone: A Man's Guide and Beyond Testosterone, ExcelMale provides evidence-based information and peer support for men navigating hormone health decisions.
 
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Some of the guys I work out with know that i inject T. It has come up why then do I not put on more gains, I do heavy rssitance training and little cardio. I explained that I am on a theraputic dose. Shoot I take a paltry 30 mg twice a week to keep red blood cells in line, so i could never do the super dosing that alot of body builders do.
At what levels do you begin to see substantial mass gains in the gym? I thought i read where guys may use 1500 mg/ injection when cycling on. I would die of a stroke in a matter of weeks doing that heavy dosage!!!

Most on trt doses are usually injecting 100-150mg/week mind you everyone does not use the same injection frequency as some inject once weekly, twice weekly (every 3.5 days), three times weekly (M/W/F), EOD, or even daily as they split up their weekly doses. Mind you there are some who inject higher doses than 150mg/week and are using up to 200mg/week but that dose is not common as it would put most men's FT levels very high/absurdly high. Trt doses generally put a man's testosterone levels in the physiological/slightly supra-physiological range and using injections tends to cause supra-physiological peaks (short-lived) which can be lessened by injecting more frequently with smaller doses of testosterone as this will result in more stable blood levels and soften the peaks/valleys and one would end up with less drastic variances between peak and trough levels. Trt doses allowing one to reach the high-end/slightly supra-physiological range usually allow one to build some muscle/lose body fat especially when lifting weights and diet is in check. Trt can result in good body composition changes (more muscle/less fat) but to really start to see an increase in muscle/strength one would have to inject doses of testosterone to cause blood levels to remain well into the supra-physiological range and the higher the better improvements to a certain degree and the doses required are usually a minimum of 200mg/week but on average 250-600mg/week are the doses where one would really start to see drastic improvements in muscle/strength gains. Mind you genetics still plays a critical role as some can use doses on the lower end of 250mg/week and see great results whereas others may need amounts in the higher end of 400-600mg/week. It is more common for amateur/pro bodybuilders to use the insane doses of 1000+ mg/week of testosterone let alone stacking of various AAS (injectables/orals) as most average gym rats are not using these insane amounts mind you they may also be stacking testosterone with other AAS (injectables/orals). Diet is also critical to gaining muscle mass when using testosterone as one would need a surplus of calories and enough protein to see results.
 
Some of the guys I work out with know that i inject T. It has come up why then do I not put on more gains, I do heavy rssitance training and little cardio. I explained that I am on a theraputic dose. Shoot I take a paltry 30 mg twice a week to keep red blood cells in line, so i could never do the super dosing that alot of body builders do.
At what levels do you begin to see substantial mass gains in the gym? I thought i read where guys may use 1500 mg/ injection when cycling on. I would die of a stroke in a matter of weeks doing that heavy dosage!!!

Keep in mind that there a lot of other reasons you gain- diet, types of lifts you do, genetics, sleep and recovery etc. I am older, but have T levels that run between 700 - 800, so I thought that I’d gain size. I have gained a lot of muscle in the past year and a half, but minimal size. What I have gained is energy, strength, and density. You may just take longer to gain. How long have you been on TRT? I had minimal gains for about 6 months and when changes started, it was in muscularity, not size.

You may may have to be patient, squat and deadlift a little more. If you are younger that 35, I’d guess the answer lies in your routines and diet. If you are older, be satisfied with getting shredded. It’s cool to be an old guy that horrifies people when he takes off his shirt.
 
Keep in mind that there a lot of other reasons you gain- diet, types of lifts you do, genetics, sleep and recovery etc. I am older, but have T levels that run between 700 - 800, so I thought that I'd gain size. I have gained a lot of muscle in the past year and a half, but minimal size. What I have gained is energy, strength, and density. You may just take longer to gain. How long have you been on TRT? I had minimal gains for about 6 months and when changes started, it was in muscularity, not size.

You may may have to be patient, squat and deadlift a little more. If you are younger that 35, I'd guess the answer lies in your routines and diet. If you are older, be satisfied with getting shredded. It's cool to be an old guy that horrifies people when he takes off his shirt.

I like being the middle aged guy that horrifies in an T-shirt... :)... With a pump my arms are close to 20 inches... I get looks but I honestly just think people are looking at me like I am a freak but I'll still take it!!! I am starting to lean and using the stack religiously and I'm starting to get VERY vascular too...
 
I like being the middle aged guy that horrifies in an T-shirt... :)... With a pump my arms are close to 20 inches... I get looks but I honestly just think people are looking at me like I am a freak but I'll still take it!!! I am starting to lean and using the stack religiously and I'm starting to get VERY vascular too...


Care to elaborate on the bolded?
 
30 mg injected twice a week is only going to suppress HPTA and not provide enough supplementation for you to see any benefit from TRT whatsoever.

At the very least 50 mg twice weekly would serve you much better and healthier as well.
 
I like being the middle aged guy that horrifies in an T-shirt... :)... With a pump my arms are close to 20 inches... I get looks but I honestly just think people are looking at me like I am a freak but I'll still take it!!! I am starting to lean and using the stack religiously and I'm starting to get VERY vascular too...

Yes, you are that guy. Nice work!
 
125 mg per week was found to make significant muscle gains in young men
Responses of different doses of testosterone injections on body composition, strength, etc.

Looking at the graph for changes in fat free mass the 125 mg/week group and 300 mg/week group resulted in significant changes compared to the 25 mg/week and 50 mg/week group which is understandable as 25 mg (very low dose) and 50 mg (low for the majority) are low doses which would result in sub-par testosterone levels and the 600 mg/week group resulted in significant changes compared to all other groups (25 mg/50 mg/125 mg/300 mg). Significant is somewhat misleading as there was a big change at 125 mg/week, slightly better at 300 mg/week and much better at 600 mg/week. I think that therapeutic doses (100-150 mg/week) for most would result in body composition changes but I would not necessarily say significant. I still think that 200 mg/week minimum would be the dose where one would really notice big changes in muscle growth as this is where the true anabolic effects of T would start to shine. Even then most cycling T/AAS for the main purpose of building muscle/strength on average are injecting 400-600 mg of T/week and the serum levels achieved steady-state 24/7 is where one would notice the best gains. Of course training/diet are key to increasing muscle gain/strength but ones genetics will always have the final say as some can grow really well using doses on the minimal end (200-250 mg/week) where as others need much higher levels (400-600 mg/week) to attain results. If 125 mg/week let alone 150 mg/week resulted in truly significant gains in muscle then no one would use/abuse T/AAS as everyone would be basically using therapeutic doses. Having ones T levels in the supra-physiological range 24/7 will result in more significant gains in muscle than one having their testosterone levels at the upper end of the physiological range. The OP was asking when one would one really start to notice substantial gains in muscle. SUBSTANTIAL is the key word to me and I would definitely say not from therapeutic doses of testosterone but supra-physiological levels whether ( 2-10x the upper end (high/normal) of the physiological range.
 
Actually i feel famtastic at this doseage, sex 2-3 times weekly, lots of energy, great metal clarity, no anxiety hct managable
I have been on test cyp for almost 4 years. Started 200 mg every two weeks. Moved to 30 mg 3.5 days and all is good.
 
Thanks mountain man. I am 54 and been on trt of almost 4 years. My T rums mod 500's on thi slow dose and hct is manageable. I have put on some mass and definition. I was just wondering what level it is to make suprphysical gains. I will never go there, just curious
 
Most on trt doses are usually injecting 100-150mg/week mind you everyone does not use the same injection frequency as some inject once weekly/twice weekly(every 3.5 days)/three times weekly(M/W/F)/EOD or even daily as they split up there weekly doses. Mind you there are some who inject slightly higher doses than 150mg/week as some with low shbg need higher doses to reach high/normal physiological testosterone levels and are using up to 200mg/week but that dose is not common as it would put most in the supra-physiological range. Trt doses generally put a mans testosterone levels in the physiological range whether mid/normal to high/normal and using injections tends to cause supra-physiological peaks (short lived) which can be lessened by injecting more frequently with smaller doses of testosterone as this will result in more stable blood levels and soften the peaks/valleys and one would end up with less drastic variances between peak and trough levels. Trt doses allowing one to reach the high/normal physiological range usually allow one to build some muscle/lose body fat especially when lifting weights and diet is in check. Trt can result in good body composition changes (more muscle/less fat) but to really start to see an increase in muscle/strength one would have to inject doses of testosterone to cause blood levels to remain in the supra-physiological range and the higher the better improvements to a certain degree and the doses required are usually a minimum of 200mg/week but on average 250-500mg/week are the doses where one woulkd really start to see drastic improvements in muscle/strength gains. Mind you genetics still plays a critical role as some can use doses on the lower end 200-250mg/week and see great results where as others may need amounts in the higher end 400-500mg/week. It is more common for amateur/pro bodybuilders to use the insane doses of 1000mg/week of testosterone let alone stacking of various aas (injectables/orals) as most average gym rats are not using these insane amounts mind you they may also be stacking testosterone with other aas (injectables/orals). Diet is also critical to gaining muscle mass when using testosterone as one would need a surplus of calories and enough protein to see results.
I'm 63 on 50 mgs every 3.5 days which puts me at 1100 tt the day before injection. Weather I'm an "over responder" or I need to lower my dose is for another thread I suppose. As for this topic, I made good gains in the gym at that dose since starting last Jan, putting on about 5 lbs of muscle. In May I wanted to try upping the dose to see the results as I had lifted "natural" all my life. I can tell you just going from 100 mgs to 200mgs was significant if not dramatic in what I looked like. It was like a 24 hour a day pump. I only stayed on that higher dose for about a month.
 
I'm 63 on 50 mgs every 3.5 days which puts me at 1100 tt the day before injection. Weather I'm an "over responder" or I need to lower my dose is for another thread I suppose. As for this topic, I made good gains in the gym at that dose since starting last Jan, putting on about 5 lbs of muscle. In May I wanted to try upping the dose to see the results as I had lifted "natural" all my life. I can tell you just going from 100 mgs to 200mgs was significant if not dramatic in what I looked like. It was like a 24 hour a day pump. I only stayed on that higher dose for about a month.

Interesting.I'm the same age and hive toyed with trying this. Did you experience any side effects or problem? I do 100 mg weekly. Results have been good, but hard not to consider pushing it a bit.
 
I didn't experience any sides, I did blood work about 6 weeks after I went back to the 100mgs and everything was normal

I have noticed the difference between 90 mg and 110 mg once per week. My energy is much better when dose is higher. So, you noticed more strength and size? My libido has been great, but I'm not sure I want it to be any higher. How did the higher dose impact size, strength and libido?
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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