Whacky blood work, any ideas what happened?

Stoak

Active Member
I have been on TRT for years with a break to make a baby. I can guess my numbers based on the dose and they have been really consistent. My standard dose has been 80mg cyp E3.5D w/250ish HCG (this part has varied) and sometimes .125-.25mg adex.

I resumed TRT end of summer on (80mg + 300iu pregnyl + .25 adex) E3.5 days and had my bloodwork done 8 weeks in. Perfectly predictable for me. Without the adex I get a similar number and my E2 is 35-40. I have had tons of bloods.

TT = 1000
E2 = 20

I decided after this 8 weeks to cycle (I know, wrong forum!) which I detailed in the Primo for E2 control thread. I used 200 test and 150 primo + 500 HCG e3.5D. I did that for 10 weeks with great results. I wanted to try a lower test dose for my next bloods and my uro was getting itchy with me at 1000 TT so I dropped to 70mg E3.5D + 500 HCG and then had bloods drawn 8 weeks later and my TT came back >1500 and E2 55! I have no idea how this happened unless using HCG 500iu E3.5 for so long really really really really boosted my natural production? I expected to see a number in 700-800 range on 140 mg per week. Is there ANY way that I still had a build up of test from the 10 week cycle before (it had been 8 weeks since my last test/primo shot). I'm really at a loss. I knew something was off bc I started to get acne as soon as I switched from the test primo cycle to the lower TRT dose (myE2 went to 55 from 26 using the primo as an AI).

Any ideas?
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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