Using two different PDE5 Inhibitors.

crash1270

Member
I have been using tadalafil in small doses daily for the nitric oxide stack promoted on this site. I definitely see benefits in erection quality. I have been considering using sildanafil prior to activity in the bedroom. Any oppinions whether this would be good or bad idea. Mostly considering this for a little boost on occasion like the weekend or special evenings. Thanks
 
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If the small daily, I assume 5mg isnt enough, it's not for me, I'd increase the dose over mixing two type. I'd use 10, or 15mg if 5 isn't enough. Remember Tadalafil is long acting, 36hrs appx.
 
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Im sure at some point I've done it, but it was probably a (AM) 10mg Tadalafil, and (PM) 25mg Sildenafil combo with arginine/citrulline in the 5g range
 
While it is frowned upon to mix these drugs as it increases the possibility of priapism and blood pressure issues, as long as it is done sensibly and one is not using too much of each, it shouldn't be that much of a concern. I'm not a doctor, so it is just my opinion. Now if one took the highest recommended dosage of each, that might be a problem.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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