Update on Kyzatrex/T cyp hybrid protocol

ignition · Aug 26, 2025

Super brief history: TRT 8 years, previously Topical then 7 years injections, T cyp. Eventually moved to to Cataceous' Enanthate/Prop blend, with a bit higher ratio of prop. Ended up doing really well at 7mg/daily.

Except HCT. Had to get off the phlebotomy train.

Was a real challenge to find a good provider for Kyzatrex, took many months.

Started on 200mg 2/day, was way too high and over stimulated. Felt like Adrenals were stressed, spiking/crashing daily. Peak levels were supra physiological with Free T at 39

Reduced to 100mg 2/day. better, but on the side of too little and daily cyclical fatigue. Got labs at trough:
-Testosterone, Total, LC/MS 135.4ng/dL 264.0-916.0 Low
-Testosterone, Free 4.93, 5.00-21.00

Tried 3x a day, kept me awake at night.

So added 5mg T cyp E3D then labs, then bumped to 6mg then labs (below), now bumping to 7mg T cyp E3D with 100mg Kyzatrex 2/day. Doing quite well. Nothing symptomatic to complain about. Just bumping the injection dose to keep the daily trough out of the basement.

Current numbers, Testosterone, F Eqlib+T LC/MS:

Peak:
-Testosterone, Total, LC/MS 756.2 264.0-916.0
-Testosterone, Free 24.43 High 5.00-21.00

Trough:
-Testosterone, Total, 212.0 LC/MS A, Low
-Testosterone, Free 5.7, 5.00-21.00

HCT 49%
HGB 17.6 g/dl

ignition · 2025-09-27T13:29:32-0500

I am calling this success.

Have been on the 7mg E3D injction with 100mg kyzatrex 2/day for 6 weeks. I increased the injection from 6 to 7mg. My previous TT and FT were acceptable. I do not expect those numbers moved much with a 1mg/3 day change in dose, and am not concerned about it.

I just had CBC, with HCT at 50% and HBG at 17.6. I have not had a Therapeutic phlebotomy since last November.

I don't feel quite like superman, but my day to day energy is good enough. I have been working long physical days 7 days a week with a crash day here and there. Libido and sexual function are good.

madman · 2025-09-27T14:13:03-0500

ignition said:
I am calling this success.

Have been on the 7mg E3D injction with 100mg kyzatrex 2/day for 6 weeks. I increased the injection from 6 to 7mg. My previous TT and FT were acceptable. I do not expect those numbers moved much with a 1mg/3 day change in dose, and am not concerned about it.

I just had CBC, with HCT at 50% and HBG at 17.6. I have not had a Therapeutic phlebotomy since last November.

I don't feel quite like superman, but my day to day energy is good enough. I have been working long physical days 7 days a week with a crash day here and there. Libido and sexual function are good.

When it comes to exogenous T and minimizing elevated hematocrit what is key here is short-lived peaks followed by much lower T levels returning close to or even back to baseline.

Minimizing the time spent at peak and avoiding elevated T levels 24/7 is where it's at.

In your case dosing oral TU (Kyzatrex) 100mg BID while injecting 7 mg TC every 3 days allows you to hit shorter-lived higher-end physiological peaks and a trough that is not in the basement although your trough is in hypogonadal territory which is not a big deal if you feel descent overall.

Your peaks are shorter-lived and more importantly T levels are not high/very high 24/7.

Would be ecstatic that your energy, libido and erectile function are good!

No one was ever meant to feel like SUPERMAN on therapy!

Everyone so caught up on thinking they need to have high-end/high trough FT levels let alone high/absurdly high T 24/7!

It's a myth that needs to be put to rest.

Pushed by all those halfwits stinking up those so called mens health/HRT forums.

One needs to have realistic expectations when jumping on T-therapy especially when it comes to libido and erectile function.

As I have stated numerous times over the years the goal of TTh is to replace physiological levels through the use of exogenous T which results in relief/improvement of low-T symptoms and increased overall well-being while at the same time avoiding/minimizing any potential side-effects and keeping blood markers healthy long-term.

Yes some will need to run higher-end trough levels within reason to experience the beneficial effects of having a healthy FT level.

Comes down to the individual.

When it comes to minimizing sides especially elevated hematocrit Natesto and oral TU take the cake.

Morgentaler hit the nail on the head here!

Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Post in thread 'KYZATREX® - A NEW ORAL TESTOSTERONE & Why It's Better Than Injections'

Sep 3, 2025

Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline