Trying to do a HPTA restart with my doc…29 days in my total T is only 18:(

My tendency to trial various TRT protocols is well documented around here. It can be really hard to know what works and what doesn't work unless you are patient and give things time: GUILTY AS CHARGED!

In any case, I was recently trialing Xyosted 50mg twice a week and eventually decided to flip back to Natesto for various reasons. In the process, I decided to peal off hCG, which I have been on for years. The thinking was that if I go back on Natesto, and if I give myself time, I may be able to get my CNS component of the HPTA axis to kick back on. But, this only works off hCG.

My energy seems ok. My headaches (which plague me on various forms of TRT) are at bay. Hard to complain. On the other hand, I feel emotionally flat. Not necessarily full-on anhedonia, but just feel like the zest is lacking. Like a steak with no salt and pepper.

Part of me realizes that it's early and that with time, this emotional flatness may subside as I recover. But, part of me does not know if I can or will recover and that I generally feel more optimism on other forms of TRT.

I still believe in the various benefits of Natesto, and encourage anyone considering TRT to start with it. In my current situation, I was hoping Natesto would be a nice crutch to wean me back to normal-ish endogenous production, but feeling this way is no fun. I am not sure I am fully mentally committed to a restart. Thus a tough cross roads I have been at before. I am leaning towards again trying a more traditional form of TRT (as opposed to Natesto). I suppose it can be useful to use Natesto periodically to allow esters to clear out of the system before embarking on something new.

For anyone that has scaled back or successfully done a restart, do you recall having this emotional flatness?
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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