Truth to Nolvadex Causing Up-regulation of Progesterone Sensitvity?

[Jimstigator]

Hey fellas,

Somewhat playing on my other thread regarding HGC and gyno... is there any truth to the internet lore that taking Nolvadex/SERMs long term can up-regulate the body's sensitivity to progesterone?

I was on low dose Nolva for the better part of three years. Could the HCG and I am now taking in conjunction with test cyp be causing an increase in progesterone, which is in turn causing some severe gyno symptoms that aren't controlled by an AI, SERM, or Cabergoline? I am no longer on Nolvadex, but that's very recent, and the med is definitely still present in my body.

Thanks!
Jim

 

[Nelson Vergel]

Tamoxifen Suppresses Gonadotropin-Induced 17α-Hydroxyprogesterone Accumulation in Normal Men


Effect of tamoxifen on GH and IGF-1 serum level

 

[Jimstigator]

Appreciate the links! Bit tough for me to understand, but makes some sense. Further, I saw in Crislers Expert TRT slides that Nolva can "increase progesterone receptor density". Hopefully this is the cause of my burning nipples.

Thanks!
Jim