TRT with seasonal allergy immunotherapy

jessea1015

New Member
I am about a year into TRT. On top of TRT I started seasonal allergy sublingual (drops) immunotherapy about 2 months ago. It seems as if this affecting me mentally, also my Test numbers were cut in half. I believe that my allergies increase my anxiety and this is why I went down this road. I read a little bit about histamine increase can increase estrogen. I figure that I am taking an exponential amount of my most exact allergies. Do you think this can affect my T levels and therefore affect my mood? I almost at my peak Allergen dose at this point but still pondering quitting. Is there anyone else that has experience with this. I'm having a hard time finding info about it, and my TRT doc says it shouldnt affect it, but I disagree. Any insight?
 
In general, male sex hormones suppress allergic responses whereas female ones aggravate them; therefore, low levels of testosterone or androgens are expected in male allergic patients and high levels of estrogen and progesterone in female allergic patients.Mar 10, 2021
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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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