TRT, HCG, and DHT

Ericd306

New Member
Hi all I’m only 7 weeks into TRT with Defy. All good so far. First follow up in about 2 weeks with labs. Question for the group - I opted to keep things simple and start with just T Cyp @ 80mg twice per week (I have high SHBG). Again, things are going well and couldn’t care less about testicular atrophy (cosmetically) and we already have 3 kids. However, I’ve been reading a lot about how “mandatory” HCG is for LH receptors, etc. I plan to talk to defy about this, but did want to understand if T only without HCG will have a negative impact (lower) my DHT levels. Prior to Clomid monotherapy about 9 years ago, my DHT was below normal with TT around 470. I’m assuming that as long as my TT is high or high-normal, DHT will follow, but wanted to make sure I’m not making the wrong assumption as I’m brand new to TRT and don’t plan on adding HCG at the moment.

Thanks!
 
Dht should follow T to some degree. Hcg would probably raise your T further and hence your dht a little further.
 
I’ve personally never heard of HCG increasing DHT more than testosterone will. My DHT just follows my T. So as my T goes up, so does my DHT. My DHT is usually over the top of the normal range. I’m sure everyone converts to DHT differently though. But I’ve personally never heard of HCG directly stimulating DHT production.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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