Can Topical DHT gel replace an AI?

TrevorTRT

New Member
For men out there like myself who struggle with easily crashing their E2 on an AI (even with microdoses), yet still experience high E2 symptoms (itchy, sensitive nips, bloating etc) can topical DHT be used to replace an AI?

I’ve found that using topical DHT eliminates any E2 sides that inexperience yet it doesn’t crash my E2 regardless of how high I dose it. Right now my DHT levels are > 900ng/dL on 20% DHT gel and I feel amazing.

Is this a long term sustainable solution which can be used as an alternative to an AI? Was wondering if DHT could technically replace an AI when blast doses of 500mg/week + of Testosterone are used?

Would appreciate anyone’s feedback or personal experience here.
 
Thanks for sharing this. I wonder how using both Proviron and DHT gel together would be.

I may add 50mg per day of Proviron to my current protocol.
In terms of TRT I would use the lowest dose possible to treat symptoms. I have no experience with DHT gel. Dosing seems easier with proviron.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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