TRT for physician assistants and nurse practitioners

madman

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Testosterone replacement therapy for physician assistants and nurse practitioners
Libert Ramos, Amir Shahreza Patel, Ranjith Ramasamy

Abstract: Physician assistants (PA) and nurse practitioners have been moving toward specialty practices, like urology. With increased training and education, they manage more complex conditions independently. Whether they are the primary provider or the follow up to a specialist, physician extenders can play a vital role in managing patients undergoing testosterone therapy. Physician extenders should be able to understand the indications, risks and associated adverse effects of administering testosterone in order to proficiently take care of patients with low testosterone. The goal of this review is to recognize the role and the limits to which physician extenders should manage hypogonadism, and when physician collaboration or referral is necessary.


Physician extenders are a growing force in healthcare today, often going beyond their initial role of complementing the growing shortage of primary care physicians (PCP). Currently, many physician assistants (PA) and nurse practitioners (NP) are moving toward specialty practices. However, mainstream curricula for PAs and NPs provide limited education in the specialty fields (1). Hypogonadism is a very common chief complaint in both endocrinology and urology (2). Of the males above age 40 who tested their testosterone levels, the incidence of low testosterone was 40% (3). Well trained PAs and NPs can manage most cases of hypogonadism requiring testosterone replacement therapy (TRT) independently. The goal of this review is to recognize the role and the limits to which physician extenders should be managing hypogonadism, and when physician collaboration or referral is necessary (4).




*Introduction to testosterone and hypogonadism

*Guidelines for TRT

- Diagnosis
- Treatment
- Contraindications and adverse effect


*Financial benefits





Conclusions


Symptomatic hypogonadism is a common complaint in urology offices and TRT is the gold standard of treatment. Physician extenders, like NPs and PAs, are capable of independently diagnosing and evaluating men with low testosterone levels and starting them on TRT when appropriate. It is vital that physician extenders understand the indications, risks, and adverse effects to ensure that patients are counselled and treated appropriately. Physician extenders must be familiar with the guidelines and recommendations about monitoring patients on TRT and must clearly understand when to consult and refer the patient to a specialist. Physician extenders do play an important role in the safe management of patients on TRT, as long as a proper treatment algorithm is established by the physician.
 
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Figure 1 A flowchart demonstrating the HPG axis and shows the negative feedback effect of testosterone and inhibin on FSH, LH, and GnRH production. It also illustrates the changes that take place that could lead to the development of age-related (late-onset) hypogonadism (8). GnRH, gonadotropin-releasing hormone; HPG, hypothalamic-pituitary-gonadal; FSH, follicle-stimulating hormone; LH, luteinizing hormone; T, testosterone.
Screenshot (2403).webp
 
Table 1 The different preparations of testosterone are shown with the advantages, disadvantages, and insurance coverage of each type (7,9)
Screenshot (2404).webp
 
Table 2 Indications and contraindications for the use of testosterone therapy in patients are the following (7,15)
Screenshot (2405).webp
 
Figure 2 A flowchart showing the sequence to follow when determining if a patient is suitable for TRT and the methods of administration. The key things to look out for on follow up are also noted, with the appropriate treatment modifications if they are found. TRT, testosterone replacement therapy; PCa, prostate cancer; CVD, cardiovascular disease; T, testosterone; FSH, follicle-stimulating hormone; LH, luteinizing hormone; E, estradiol; Hct, hematocrit; PSA, prostate-specific antigen; QD, 4 times daily; IM, intramuscular injection.
Screenshot (2407).webp
 
Well it's a start, but looks a bit archaic:

-Treatment decision based on TT, not FT
-does not mention SubQ,
-Only T cyp/enth dose recommendation is 100 or 150mg/week, implying single weekly dose
-recommends anastrozole in 1mg doses for elevated E2
-Does not mention testicular atrophy and it's management
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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