TRT and Serotonin

[S1W]

I'm curious to know whether or not long-term HPTA shutdown, or some other mechanism from long-term TRT, has any effect on brain serotonin levels, serotonin transmitters, or the brain's ability to uptake serotonin.

Anyone have any insight here?

@Mountain Man ?

 

[Vince]

TRT and Neurotransmitter Balance - Excel Male TRT Forum

What effects, if any, does TRT have on neurotransmitters, particularly on serotonin? I know that in the initial stages of TRT, there is a pronounced effect on dopamine - I have been told that this is what causes the "honeymoon" that many guys experience. Are there neurotransmitter...

www.excelmale.com

 

[Mountain Man]

I'm curious to know whether or not long-term HPTA shutdown, or some other mechanism from long-term TRT, has any effect on brain serotonin levels, serotonin transmitters, or the brain's ability to uptake serotonin.

Anyone have any insight here?

@Mountain Man ?

This question prompted me to research. In my work, I can tell by looking at guy whether or not he is low T and if he has sleep apnea. I am usually correct and can’t remember the last time my hunch was wrong. There is a low testosterone and depression link, but there are other things I like my clients to do first. Clean up diet, begin to exercise, particularly something accessible that they will do at home in the morning, some journaling exercises for a few morning and evening minutes, and some skills building around communication and thinking habits.

it does appear that there is a link, but going on TRT is only one intervention and no medical intervention alone, whether meds or TRT, will work for long. These are tools to build the mental and emotional energy to do the above tasks of diet, exercise, and though monitoring.

Here’s a recent study that sheds some light:

Testosterone levels in healthy men correlate negatively with serotonin 4 receptor binding - PubMed

The serotonergic system integrates sex steroid information and plays a central role in mood and stress regulation, cognition, appetite and sleep. This interplay may be critical for likelihood of developing depressive episodes, at least in a subgroup of sensitive individuals. The serotonin 4...

pubmed.ncbi.nlm.nih.gov