madman
Super Moderator
Must listen for any man struggling with sides on ADT!
08:48 Why Men Need Estradiol
* Why men need estradiol for *brain, bone, sexual, and overall health.*
What if one of the hardest parts of androgen deprivation therapy is not simply low testosterone—but the loss of estradiol that comes with it?
Dr. Richard Wassersug brings a rare dual perspective to that question.
He is a PhD evolutionary biologist, former professor of anatomy and neurobiology, prostate cancer quality-of-life researcher, co-developer of an androgen deprivation education program, and a patient who has used transdermal estradiol for more than two decades. His experience helped drive a deeper investigation into whether estrogen delivered through the skin could suppress testosterone while avoiding some of the burdens associated with standard LHRH-based ADT.
In this episode, you’ll learn:
* Why men need estradiol for *brain, bone, sexual, and overall health.*
* What the *PATCH research* suggests about transdermal estradiol, cancer control, and quality of life.
* Why *hot flashes, poor sleep, fatigue, and cognitive symptoms* may reflect more than testosterone loss.
* What men should know about *gynecomastia, monitoring, exercise, and shared decision-making* before considering this emerging strategy.decision-making before considering this emerging strategy.
CHAPTERS
00:00 ADT Side Effects Question
00:54 Podcast Disclaimers
01:33 Meet Dr Wassersug
03:59 Diagnosis And Early Treatment
04:58 Finding Estradiol Research
07:29 Lupron Side Effects And Sleep
08:48 Why Men Need Estradiol
11:00 Switching To Estradiol
15:13 NEJM Patch Trial Breakdown
20:53 Gynecomastia And Management
24:07 Real World Patient Stories
25:20 Sponsor Message Break
27:51 Access Barriers And Limits
29:03 ADT Protocols and Sleep
31:32 Estradiol Targets and Ratios
37:23 Patch vs Gel Dosing
39:10 Combining ADT With Estradiol
42:52 Who Benefits Most
44:18 PATCH Study Scope and Add-Ons
47:33 Getting Estradiol Prescribed
50:23 Suffering Mindset and Sexual Health
54:48 Active Surveillance Trial Ideas
08:48 Why Men Need Estradiol
* Why men need estradiol for *brain, bone, sexual, and overall health.*
What if one of the hardest parts of androgen deprivation therapy is not simply low testosterone—but the loss of estradiol that comes with it?
Dr. Richard Wassersug brings a rare dual perspective to that question.
He is a PhD evolutionary biologist, former professor of anatomy and neurobiology, prostate cancer quality-of-life researcher, co-developer of an androgen deprivation education program, and a patient who has used transdermal estradiol for more than two decades. His experience helped drive a deeper investigation into whether estrogen delivered through the skin could suppress testosterone while avoiding some of the burdens associated with standard LHRH-based ADT.
In this episode, you’ll learn:
* Why men need estradiol for *brain, bone, sexual, and overall health.*
* What the *PATCH research* suggests about transdermal estradiol, cancer control, and quality of life.
* Why *hot flashes, poor sleep, fatigue, and cognitive symptoms* may reflect more than testosterone loss.
* What men should know about *gynecomastia, monitoring, exercise, and shared decision-making* before considering this emerging strategy.decision-making before considering this emerging strategy.
CHAPTERS
00:00 ADT Side Effects Question
00:54 Podcast Disclaimers
01:33 Meet Dr Wassersug
03:59 Diagnosis And Early Treatment
04:58 Finding Estradiol Research
07:29 Lupron Side Effects And Sleep
08:48 Why Men Need Estradiol
11:00 Switching To Estradiol
15:13 NEJM Patch Trial Breakdown
20:53 Gynecomastia And Management
24:07 Real World Patient Stories
25:20 Sponsor Message Break
27:51 Access Barriers And Limits
29:03 ADT Protocols and Sleep
31:32 Estradiol Targets and Ratios
37:23 Patch vs Gel Dosing
39:10 Combining ADT With Estradiol
42:52 Who Benefits Most
44:18 PATCH Study Scope and Add-Ons
47:33 Getting Estradiol Prescribed
50:23 Suffering Mindset and Sexual Health
54:48 Active Surveillance Trial Ideas
