Total T takes a dive after a month on Androgel

Les

New Member
I started on Androgel 1.62 40.5mg daily last month with a total T of 290 (260-1600rr) and a free T of 38 (47-244rr). I felt much better the first three weeks, and slowly got back to the feelings of low motivation, energy, and drive. My total T just came back lower at 157 (260-1600rr). Still waiting on free T result. FSH 2.0 (0.7-11.1rr), LH 0.8 (0.8-7.6rr), E2 26.8, DHEA 242 (80-560rr). Things seemed promising for a while. Now what? Is it time to switch to cyp injections and/or add an AI?
 
Thanks. What about that 26.8 E2? Is that considered borderline normal/high, or is that a good place to be? I see more than one opinion of the normal level from different sources. Also read not to rub in the Androgel like a moisturizer, but apply a thin layer to the entire application site like a coat of paint and let it dry/soak in.
 
Les, many guys need 7.5 grams of Androgel. I can tell that you need more because your FSH and LH are still detectable. You may be one of them (or switch to injections if you do not want all that gel volume and potential transference to kids or women)

Yes, that estradiol is OK. Your T is low, so your E2 will be too.
 
My T levels also initially dropped after going on 1.62 after my 1st month. I was increased from 41 to 81 mg and my total t still only reached a level of 500 in four month. During those 4 months. I tried applying moisturizing lotion to increase absorption. We even contacted Abbi Pharmaceutical. Applying that much gel and having concerns about 2nd hand exposure and not getting the benefits I was expecting it was a easy decision to switch to injections. Don't get me wrong I was benefiting from the gel. Very gradual and subtle but was pleased for the improvements in feeling better. Everyone is different but I benifit much more from injections.
 
I started on Androgel 1.62 40.5mg daily last month with a total T of 290 (260-1600rr) and a free T of 38 (47-244rr). I felt much better the first three weeks, and slowly got back to the feelings of low motivation, energy, and drive. My total T just came back lower at 157 (260-1600rr). Still waiting on free T result. FSH 2.0 (0.7-11.1rr), LH 0.8 (0.8-7.6rr), E2 26.8, DHEA 242 (80-560rr). Things seemed promising for a while. Now what? Is it time to switch to cyp injections and/or add an AI?

Les read the thread I started titled "I quit my Androgel today".

I had the same problem. Initial T was 230 and it jumped to 650 within the first 2 months with my following result being back down to sub 300. We increased my dose and my next results were 289.

I have just gave up on the gel after 6 months and started the injections.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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