Total T >1500 (New Blood Test)

mopes

Member
Jesus. Time to reduce dose 20% or so? Currently on 200mg test cyp split into two subq injections, one Tuesday, one Friday. 500 IU HCG with each injection. Blood draw was on Monday. Total T >1500, Free T 39.3

One month ago when I was on compounded cream my Total T was 427 and Free T was 5.84 and Estradiol Sensitive was 10.4...
 

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How long have you been on this protocol? When did you start? I ask because your E2 (sensitive) is still very low. How did you and your doctor arrive at the current dose?
 
4 weeks on the t dose. Two weeks on hcg

A total weekly dose of 200mg per week is at the upper end of the scale for TRT. Jumping from a cream to that amount of injectable testosterone is a leap. You do have a significantly elevated SHBG, was that an issue prior to this protocol?
 
Shbg has been high for many years prior to trt and doc was comfortable with higher dose so wanted to 'mass over the top' and negate the high shbg.
 
Drop the T down to 160mg a week and the hcg to 500IU a week, both split into two doses. Then retest in two/three weeks. Sound like a reasonable course of action to you guys?
 
Drop the T down to 160mg a week and the hcg to 500IU a week, both split into two doses. Then retest in two/three weeks. Sound like a reasonable course of action to you guys?

Sounds good, but you need to wait at least four weeks - with no further changes - before testing again. Dr. Saya holds out for five weeks, as he has written here, and my doctor insists on six weeks before retesting. Four, however, is reasonable.
 
I think 4 weeks, or longer, would be ideal too just trying to balance time with additional insight into the remainder of my blood work. Anxious to see what e2, dhea-s, dht, H/H, etc look like given these high T levels.
 
I use Nettle and it has brought my SHBG down from 30's to 20's, I also take it for allergies as well. I had a similar response to topicals, sat in the 400's to 500's range with mid range free T and lower E2. I could get these numbers naturally so what was the point? I now do Test Cyp shallow IM or sub Q at 120mg per week in two doses (Tue/Fri)and my last lab draw had me at 1074 total T and 28.6 free T (8-25 reference range) with my sensitive Estradiol coming back at 41. I also run HCG M/W/F at 250 IU. Yeah, 200mg per week is going to put most men at supraphysiological levels. 120mg per week in two doses seems to be my sweet spot, I actually came up with my protocol and my prescribing TRT doc agrees and gives his input. I am also counseling with Defy as well in case I want to do a restart in the future. We will see if Dr. Crisler wants to made any adjustments to my protocol here in a few weeks.
 
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Nettle if fantastic stuff, keeps my allergies in check and also give you more free T. I use two brands for Nettle.

Redd Remedies Adult Sinus which has 100mg of Nettle as well as other good antioxidants. And the other brand of Nettle I use is Oregon's Wild Harvest Nettle which has 600mg of nettle per two caps. I think you want to get around 700-1000mg per day of Nettle for the free T effects.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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