Thyroid labs - need help interpreting!

get1200

New Member
I've been on TRT for about 18 months now, and something I still can't get over is fatigue - really no other bad things going on besides that. Decided to run some thyroid labs, and a bit concerned about the T4, TSH, and T3. For reference, I'm 30, and my test levels are approximately 890-940, with E2 at 19-25 (this has been my range in various labs).

T4 Free, Direct: 1.26 (range= 0.82-1.77)
TSH: 1.910 (range = 0.450-4.500)
T3 Free: 3.4 (range = 2.0-4.4)

Please let me know if these labs say anything at all - I know I didn't test Reverse T3 in this one, but I will if needed.

Thanks!
 
I've been on TRT for about 18 months now, and something I still can't get over is fatigue - really no other bad things going on besides that. Decided to run some thyroid labs, and a bit concerned about the T4, TSH, and T3. For reference, I'm 30, and my test levels are approximately 890-940, with E2 at 19-25 (this has been my range in various labs).

T4 Free, Direct: 1.26 (range= 0.82-1.77)
TSH: 1.910 (range = 0.450-4.500)
T3 Free: 3.4 (range = 2.0-4.4)

Please let me know if these labs say anything at all - I know I didn't test Reverse T3 in this one, but I will if needed.

Thanks!
It would be nice if your free T3 was a little higher. If it was me I would have gotten the reversed T3 checked. With the labs that you are posting, I would not take any thyroid meds.
 
You need to rerun them you can't run RT3 in isolation, you know, by itself later on. At least you shouldn't but as it is I don't see aproblem though plenty of guys are going to try and sell you the Hypo and sluggish thyroid nonsense. I'd reserve any real input until you can rerun these, if you choose to do that.
 
Numbers look pretty damn good. But unfortunately they mean very little without RT3. You need to get that full thyroid panel done again, and add in RT3. Here’s one anectodal story I found on YouTube of a girl explaining how important testing RT3 can be.

 
If you've got a good enough doctor, a therapeutic trial of NDT would certainly let you know one way or the other.
Your numbers don't look bad necessarily but then again, we all know what in range as far as Testosterone means as well.
Doesn't mean optimal for you.

And like the others said, having a look at all the thyroid numbers including RT3 would definitely help.
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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