I'm on your side of this debate, but I think we need to individually evaluate studies associating harm with higher estradiol. For example, the study finding harm with estradiol over 34 pg/mL used an immunoassay test: "A quantitative competitive immunoassay (Immulite 2000) was used to measure serum 17 estradiol and testosterone." If this test was also measuring CRP then we cannot say that the negative association is necessarily with estradiol.