madman
Super Moderator
* Our findings indicate that a decline in testosterone levels is associated with increased body weight, BMI, waist circumference, and visceral fat, as well as reduced adiponectin levels. Furthermore, regular exercise appears to play a protective role in preventing testosterone decline.
EFFECTS OF DECLINING TESTOSTERONE ON VISCERAL FAT ACCUMULATION AND THE MITIGATING ROLE OF REGULAR EXERCISE
Sohei Kuribayashi*, Cleveland, OH; Shinichiro Fukuhara,Norichika Ueda, Kentaro Takezawa, Suita, Japan; Scott Lundy,Cleveland, OH; Yasushi Miyagawa, Osaka, Japan; Norio Nonomura, Suita, Japan
INTRODUCTION AND OBJECTIVE
Testosterone production is crucial for maintaining physical and psychological health in males, with various abnormalities occurring in individuals experiencing low testosterone levels. While numerous studies have explored the cross-sectional associations between testosterone and metabolic health, there are relatively few studies that have examined the long-term changes in testosterone levels and their impact on health outcomes. In this study, we aimed to examine the longitudinal effects of changes in total testosterone (TT) levels within the same cohort.
METHODS
We conducted a longitudinal analysis of 193 male subjects who visited our hospital multiple times between 2018 and 2023 for medical checkups for at least 3 years. Participants were divided into four quartiles (Q1, Q2, Q3, Q4) based on changes in TT (ΔTT) from baseline to the final visit. Additionally, we assessed participants' physical activity by recording whether they engaged in at least 20 minutes of exercise weekly. We compared TT changes between those who exercised regularly and those who did not.
RESULTS
The median age at baseline was 61 years, and the median baseline TT was 4.75 ng/mL. The median ΔTT was −1.22, −0.35, +0.2, and +1.5 ng/mL for Q1, Q2, Q3, and Q4, respectively. We observed that participants with decreased TT experienced significant increases in body weight, body mass index (BMI), waist circumference, and visceral fat (p for trend 0.0081, 0.0147, 0.0281, and 0.0013, respectively), while their adiponectin levels decreased (p for trend 0.0336). Participants engaging in at least 20 minutes of exercise weekly demonstrated significantly smaller declines in TT compared to those who did not exercise regularly (p < 0.05). These results suggest that physical activity may mitigate testosterone decline over time.
CONCLUSIONS
Our findings indicate that a decline in testosterone levels is associated with increased body weight, BMI, waist circumference, and visceral fat, as well as reduced adiponectin levels. Furthermore, regular exercise appears to play a protective role in preventing testosterone decline. Therefore, maintaining testosterone levels through lifestyle modifications, including physical activity, could be an effective strategy for reducing visceral fat accumulation and improving metabolic health in aging males.
EFFECTS OF DECLINING TESTOSTERONE ON VISCERAL FAT ACCUMULATION AND THE MITIGATING ROLE OF REGULAR EXERCISE
Sohei Kuribayashi*, Cleveland, OH; Shinichiro Fukuhara,Norichika Ueda, Kentaro Takezawa, Suita, Japan; Scott Lundy,Cleveland, OH; Yasushi Miyagawa, Osaka, Japan; Norio Nonomura, Suita, Japan
INTRODUCTION AND OBJECTIVE
Testosterone production is crucial for maintaining physical and psychological health in males, with various abnormalities occurring in individuals experiencing low testosterone levels. While numerous studies have explored the cross-sectional associations between testosterone and metabolic health, there are relatively few studies that have examined the long-term changes in testosterone levels and their impact on health outcomes. In this study, we aimed to examine the longitudinal effects of changes in total testosterone (TT) levels within the same cohort.
METHODS
We conducted a longitudinal analysis of 193 male subjects who visited our hospital multiple times between 2018 and 2023 for medical checkups for at least 3 years. Participants were divided into four quartiles (Q1, Q2, Q3, Q4) based on changes in TT (ΔTT) from baseline to the final visit. Additionally, we assessed participants' physical activity by recording whether they engaged in at least 20 minutes of exercise weekly. We compared TT changes between those who exercised regularly and those who did not.
RESULTS
The median age at baseline was 61 years, and the median baseline TT was 4.75 ng/mL. The median ΔTT was −1.22, −0.35, +0.2, and +1.5 ng/mL for Q1, Q2, Q3, and Q4, respectively. We observed that participants with decreased TT experienced significant increases in body weight, body mass index (BMI), waist circumference, and visceral fat (p for trend 0.0081, 0.0147, 0.0281, and 0.0013, respectively), while their adiponectin levels decreased (p for trend 0.0336). Participants engaging in at least 20 minutes of exercise weekly demonstrated significantly smaller declines in TT compared to those who did not exercise regularly (p < 0.05). These results suggest that physical activity may mitigate testosterone decline over time.
CONCLUSIONS
Our findings indicate that a decline in testosterone levels is associated with increased body weight, BMI, waist circumference, and visceral fat, as well as reduced adiponectin levels. Furthermore, regular exercise appears to play a protective role in preventing testosterone decline. Therefore, maintaining testosterone levels through lifestyle modifications, including physical activity, could be an effective strategy for reducing visceral fat accumulation and improving metabolic health in aging males.
