The Testosterone Crash: Dr. Mohit Khera on Low T, ED “Warning Signs,” TRT Safety, TRAVERSE Trial, and the Future of Men’s Health

madman

Super Moderator

In this episode, Dr. Alex Tatem sits down with world-renowned men’s health expert Dr. Mohit Khera to break down the real science behind testosterone — why men’s levels keep dropping, how to correctly diagnose Low T, the role of free vs total testosterone, the safety of TRT, and what the TRAVERSE Trial actually proved.

They also dive deep into ED as an early warning sign, fertility risks, compounding pharmacies, injectable vs topical testosterone, super-physiologic dosing, and the future of men’s health.
Chapters

00:00 – Why Testosterone Levels Are Declining
01:20 – What “Low T” Really Means
03:50 – Total Testosterone vs Free Testosterone
06:40 – Low T as a Warning Sign for Overall Health
09:50 – ED & Semen Analysis: The 3 Canaries in Men’s Health
12:50 – Lifestyle Changes That Improve Sexual & Hormonal Health
15:20 – TRT Options + Fertility Considerations
16:50 – 503A vs 503B Compounding Pharmacies
19:10 – Is TRT Safe? Breaking Down the Evidence
20:55 – TRAVERSE Trial Results Explained
24:20 – Topical vs Injectable Testosterone
26:10 – Risks of Supraphysiologic Testosterone Dosing
27:45 – The Future of Testosterone Therapy & Men’s Health
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Online statistics

Members online
4
Guests online
525
Total visitors
529

Latest posts

Beyond Testosterone Podcast

Back
Top