Dr. Mohit Khera, MD: How Low Testosterone Influences Mental & Sexual Health

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In this conversation, Dr. Mohit Khera discusses the critical role of testosterone in men's health, its implications for various comorbid conditions, and the importance of lifestyle modifications. He emphasizes the need for regular testosterone level checks, especially for men over 40, and explores the interplay between testosterone and mental health.




This episode also covers:

  • The definition of low testosterone
  • Underlying causes of low testosterone, including obesity and stress
  • How to optimize testosterone levels with a holistic approach that includes diet, exercise, sleep, and stress management
  • The critical relationship between health span, sexual health, and preventative care
  • The importance of early screening for conditions like erectile dysfunction, which can signal underlying cardiovascular issues
  • The interconnectedness of hormonal health, particularly the balance of testosterone, estrogen, and progesterone



Key Moments :

00:00 Introduction to Dr. Mohit Khera
00:53 The Importance of Testosterone in Men's Health
03:12 Testosterone and Comorbid Conditions
06:23 The Interplay of Testosterone and Mental Health
08:09 Defining Low Testosterone
10:32 Understanding Testosterone Receptor Sensitivity
12:18 Optimizing Testosterone Levels
14:12 Concerns About Testosterone Over-Prescription
16:08 Underlying Causes of Low Testosterone
20:02 Symptoms of Low Testosterone
22:27 Lifestyle Modifications for Testosterone Optimization
23:24 The Importance of Health Span and Sexual Health
24:42 Early Screening and Preventative Care
25:53 Erectile Dysfunction as a Warning Sign
29:44 Testosterone in Women: A Neglected Topic
32:02 The Stigma Around Female Testosterone Therapy
35:12 Potential Benefits of Testosterone for Women
39:49 The Triangle of Hormonal Health: T, E, and P
 
* if the CAG repeat is >27 that patient has an insensitive receptor




10:32 Understanding Testosterone Receptor Sensitivity
12:18 Optimizing Testosterone Levels
14:12 Concerns About Testosterone Over-Prescription




 
* The triangle is testosterone, estradiol and progesterone




29:44 Testosterone in Women: A Neglected Topic
32:02 The Stigma Around Female Testosterone Therapy
35:12 Potential Benefits of Testosterone for Women
39:49 The Triangle of Hormonal Health: T, E, and P
 




 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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