The Difference Between Free and Total Testosterone with Dr. Abe Morgentaler

[madman]

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Do you know the difference between free and total testosterone?

Most people don't, but it's an important distinction. Watch this video to learn more about these two measures of testosterone and what they mean.

 

[Nelson Vergel]

I love that guy !

 

[tareload]

A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications

This appraisal of the dynamics of testosterone binding to proteins and of the free hormone hypothesis offers guidance for the application of free testoster

academic.oup.com

Test Dosage vs Levels for Cycle Recommendation

Sorry I’m late to the party. Good topic and that’s why I made this topic: Problem with answering this question is no one really knows how T:SHBG interaction really works and there’s no harmonized methods for measuring free T. You’ve got a lot of people throwing out their fT numbers and have...

forums.t-nation.com

See posts 93 to 99.

Discussion in interview above incomplete.

Test Dosage vs Levels for Cycle Recommendation

Nice read: [URL unfurl=“true”]https://academic.oup.com/edrv/article/38/4/297/4071740?login=true[/URL] Excerpts: As I wagered with “madman” in the past on ExcelMale, I’m betting we still have a ways to go before harmonized fT levels make their way into mainstream clinical decision making.

forums.t-nation.com

 

[tareload]

Test Dosage vs Levels for Cycle Recommendation

See first two pages of review article above. Bioavailable (“free” + “weakly bound”) T assay is a very standard result that attempts to measure non-SHBG bound testosterone by precipitating SHBG bound fraction using ammonium sulfate method...

forums.t-nation.com

 

[tropicaldaze1950]

Is there an 'optimal' amount of free T? Dr. Morgentaler alludes to men who have a decent total T but are still symptomatic(fatigue, no morning erections, low libido, etc). What I've understood is that increasing the dosage of T will lower SHBG and increase free T. I was hoping that Dr. Morgentaler would cite specific numbers in regards to free T. And is it specific to each man, where one might feel great with a free T of 250 pg/mL, but another man needs 350 or 400 or 500(pg/mL), which would translate into a higher dose, thus a supra high total T.

 

[tareload]

Is there an 'optimal' amount of free T?

Somewhere south of a bulging purple hypertensive crisis and north of walking dead with no libido, energy or function down below. Unless the individual in question is into either of those options. That is a good question.

Always put units on your numbers.

 

[madman]

Testosterone & Men's Health

www.excelmale.com