Testosterone transdermals... which one is "best"?

granger

Active Member
eh folks, can ignore this first paragraph pre amble:

tried natesto for a good while even though was crystalized i was told "its fine" but unfortunately my bloods dont agree (as did the feeling), super strange as took a break for 10 days or so and when started up again REALLY started to feel it again(i know many possible reasons).. anyway i took a break as had what was a run away heart beat and got cold hands and full on fight or flight, this came and went for a couple days got better for a week as a stopped then I started natesto again and it SLOWLY started to come back. at first i thought maybe thyroid or something weird as was not stressed and happened after I ate a big supper. (blood glucose is fine 5.8 or so during this weird feeling) ive had anxiety but this was dif as sorta twinge and of course makes you feel like having a jammer, but go for a walk and resolves(except 1st one i think i had adrenal dump and felt that for a few days).. I found several people that have had that happen on natesto.. im sure it has something to do with random dosing as VERY up and down ie at 5-6 hours after your dose (esp if REALLY felt the morning dose) you really feel foggy and tired.

That is all to say i think im going to try some transdermal (i just really wanted natesto to work to keep fertility as was not even using 3x a day regime and 100% happy with lower doses).

any preferences on transdermals? compounded PLO? androgel? I liked the idea of that applicator type but is no longer available in canada. or preferably one that is quicker onset and leaves the system quicker (hopefully to keep some of the sleeping pulse at least).
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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