madman
Super Moderator

Testosterone Therapy in High-Risk Men for Prostate Cancer
A video from Edoardo Pozzi, posted on Mar 25, 2025.

Poor metabolic health is a major risk factor for prostate cancer, which results in high levels of insulin (one of the most potent growth factors for cancer), inflammation, etc.
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Triglyceride-glucose index is a predictor of the risk of prostate cancer: a retrospective study based on a transprostatic aspiration biopsy population - PubMed
TyG index and age are risk factors for prostate cancer, and the interaction between the TyG index and different risk factors may increase the risk of prostate cancer. TyG index has some predictive value for the risk of prostate cancer, and the risk of prostate cancer can be reduced by...pubmed.ncbi.nlm.nih.gov
TRT is not. Men with active prostate cancer are even being treated with TRT now without any adverse effects on progression or mortality:
Oncologic Outcomes of Testosterone Therapy for Men on Active Surveillance for Prostate Cancer: A Population-based Analysis - PMC
In this population-based study, testosterone therapy for men on active surveillance for prostate cancer did not worsen mortality. Keywords: Testosterone, Prostate cancer, Outcomes, Active surveillancepmc.ncbi.nlm.nih.gov
Look into the saturation model of androgens in the prostate. It takes a very low level of serum testosterone (like serious hypogonadism) to produce intraprostate levels...
Predict estradiol, DHT, and free testosterone levels based on total testosterone
This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.
Enter your total testosterone value to see predictions
Results will appear here after calculation
A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.
The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038