Testosterone Physiology Explained: From Brain Signals to Blood Tests

madman

Super Moderator

In this video, Dr. Jonathan Clavell—board-certified urologist and men’s health specialist in Houston, Texas—breaks down exactly how testosterone works, where it comes from, how it’s regulated, and how we test and treat it.




Learn about:

• The connection between your brain and testicles that controls testosterone

• The difference between total and free testosterone

• Why timing your labs matters

• What symptoms really mean (and when they don’t mean Low T)

• Common causes of low testosterone—and what your labs can reveal

• How testosterone therapy affects red blood cells, estrogen, PSA, and more




Whether you’re dealing with fatigue, low libido, or just curious about your hormone health, this video gives you real answers without the hype.
 
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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