Testosterone (no ester) Suspension for Injection - Literature Review

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1824881/pdf/canmedaj00697-0027.pdf

 

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TESTOSTERONE PREPARATIONS WITH PROLONGED ACTIVITY12

Abstract. IT IS well known that the duration of response elicited by a given dose of hormone depends on many factors, among which are the vehicle used, int

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[Guided_by_Voices]

It would interesting to see the results (on symptoms primarily) of adding a low 1-2MG daily dose to a low dose clomid protocol. Those who respond well to low T doses might do well without much if any net T or LH suppression.

Short-acting oral anabolics might be similar as well.

 

[Bigben]

THERAPY WITH AQUEOUS SUSPENSIONS OF TESTOSTERONE

Abstract. TREATMENT of hypogonadism in males has been carried out with testosterone propionate and with methyl testosterone. The pure steroid, testosterone

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Question. After looking thru this I could not see anywhere any DHT numbers. Did I miss it? I'm just curious if suspension affects DHT differently than enanthate, cypionate or propionate. Did anyone find this??

 

[tareload]

Question. After looking thru this I could not see anywhere any DHT numbers. Did I miss it? I'm just curious if suspension affects DHT differently than enanthate, cypionate or propionate. Did anyone find this??

No you didn't miss it. These papers covered very early work before individual metabolites of testosterone were quantified.

You could take the pharmacokinetic profile of total ketosteroids above and combine with these data in this link:

Support natural T instead of replacing?

Tintin: My point was to start simple (one medication), check labs, and make adjustments. If there are several variables from the start, it will be practically impossible to get dialed in. Pick T, OR enclomiphene, and proceed from there. For some, enclomiphene is all they need. It matters if you...

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This work would be in the limit of very fast absorbing pure testosterone. As you can see E2 and DHT lag slightly but follow the qualitative behavior of the TT profile very well. Hence, E2 and DHT profiles will match very well the release rate of testosterone from the test suspension or cleavage from the ester.

 

[Bigben]

No you didn't miss it. These papers covered very early work before individual metabolites of testosterone were quantified.

You could take the pharmacokinetic profile of total ketosteroids above and combine with these data in this link:

Support natural T instead of replacing?

Tintin: My point was to start simple (one medication), check labs, and make adjustments. If there are several variables from the start, it will be practically impossible to get dialed in. Pick T, OR enclomiphene, and proceed from there. For some, enclomiphene is all they need. It matters if you...

www.excelmale.com

This work would be in the limit of very fast absorbing pure testosterone. As you can see E2 and DHT lag slightly but follow the qualitative behavior of the TT profile very well. Hence, E2 and DHT profiles will match very well the release rate of testosterone from the test suspension or cleavage from the ester.

Thank you for this. So the DHT rise would be similar to other forms of testosterone basically.

 

[Bigben]

Thank you for this. So the DHT rise would be similar to other forms of testosterone basically.

The reason I'm asking is for the hair loss. All I could find was this which shows daily sq shit increase was insignificant vs weekly shots. Was just wondering if suspension acts differently.

Daily subcutaneous testosterone for management of testosterone deficiency

Testosterone deficiency (TD) is a public health concern, a predictor of metabolic syndrome, and is associated with an increased all-cause and cardiovascular mortality. Testosterone deficiency in men is treated by a variety of methods including injectable testosterone compounds, patches, gels...

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1824881/pdf/canmedaj00697-0027.pdf

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Could you see if there is any comparison between suspension vs enanthste regarding dht being raised?

 

[Bigben]

Going to do a thread on what is often referred to as TNE (Testosterone No Ester) on here. This preparation would be crystalline testosterone in an aqueous suspension (e.g., Aquaviron). I'll see what I can find on pharmacokinetics as well.

Building off of @madman 's post here:

Advice on low dose daily testosterone

FIGURE 1 | Percent change in mean gonadotropin levels (LH & FSH), from baseline through 6 months of testosterone treatment. Nasal testosterone (blue), dosed t.i.d., adapted from (15), n = 33. Topical testosterone (orange), dosed daily, adapted from (9), n = 123. IM injectable - 100 mg...

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THERAPEUTIC USE OF TESTOSTERONE IN AQUEOUS SUSPENSION

Abstract. BOTH the male and female sex hormones are customarily dissolved in vegetable oil for the purpose of parenteral therapy. These preparations are wi

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Note the use of the term "potency" below. Early days but already good observations on the pharmacokinetics of various T form and solvents.
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Excellent find

 

[Bigben]

Excellent