Testosterone metabolism and HCG

PAUL-E

Member
I had a couple of questions.

1. Does the Human body typically metabolize exogenous testosterone at the same rate as naturally produced testosterone?

2. If not, for those like me who have to take a larger dose to get normal optimal range numbers, would we benefit from HCG

For example say if I take 220mg a week now and it puts me in the low 800's on a troft day and my pre TRT total T numbers were say 198 but the 198 possibly wouldn't metabolize as fast is it crazy to think I would be close to 1000 total or more and I would be able to lower my dose and possibly negate some side effects(back acne).

I'm asking because I have read people taking half of what I do and get better numbers and am curious why.
 
Also does anyone know if you have a medical condition that can cause the loss of BMD will that cause the testosterone to be used up faster so to speak?
 
I had a couple of questions.

1. Does the Human body typically metabolize exogenous testosterone at the same rate as naturally produced testosterone?

2. If not, for those like me who have to take a larger dose to get normal optimal range numbers, would we benefit from HCG

For example say if I take 220mg a week now and it puts me in the low 800's on a troft day and my pre TRT total T numbers were say 198 but the 198 possibly wouldn't metabolize as fast is it crazy to think I would be close to 1000 total or more and I would be able to lower my dose and possibly negate some side effects(back acne).

I'm asking because I have read people taking half of what I do and get better numbers and am curious why.

If you're inferring and please clarify that you have Endo AND EXO T in your body and they are adding up, you're dead wrong. Using HCG isn't going to have any appreciable increase in the T your testes are making, we don't use HCG with TCyp for that.

People taking half what you take, 110mg E3.5D, are taking less, and having less Estrogenic symptoms because they/we inject more frequently. EOD injections are becoming more and more common. Someone might shoot 20mg-30mg EOD and be on less than you (220mg) in a 7 day period and pull higher Total T #s.
 
If you're inferring and please clarify that you have Endo AND EXO T in your body and they are adding up, you're dead wrong. Using HCG isn't going to have any appreciable increase in the T your testes are making, we don't use HCG with TCyp for that.

People taking half what you take, 110mg E3.5D, are taking less, and having less Estrogenic symptoms because they/we inject more frequently. EOD injections are becoming more and more common. Someone might shoot 20mg-30mg EOD and be on less than you (220mg) in a 7 day period and pull higher Total T #s.

Thanks for the reply and thanks for clearing it up. I appreciate the advice but EOD injections would be a little two much for me.
I think your right about the estrogen being the factor when I first stated TRT I used anastrozole for my AI because I had a little nipple sensitivity at first(maybe just paranoid) then I crashed my Estrogen and stopped taking it after that my test dose increased to 200mg .5ml every 3.5 days no AI all my labs were good total T was around mid/upper 900s free T was good estrogen was good. I was feeling good libido was great mentally a lot better improved my relationship with family sense of well being that kind of thing.
I had to start taking another medication and it seemed like all the benefits I was getting from my TRT were gone my estrogen close to tripled (that's why I started AI again and increased to 220mg/week.) and I gained a significant amount of weight in a short period of time my BP went from normal to high. I was getting edema and finally abnormal urination (kidney issues). I quit taking that medication and went threw withdrawals but edema gone BP normal again libido good mood better getting more of the positives from TRT back and I'm losing weight I even had to cut my AI dose in half (lab confirmed) and my kidneys values are back in normal ranges I'm hoping things keep improving.
 
Regarding more frequent injections being too much, are you currently injecting IM or SQ?

EOD is one option. E3D and twice a week (3.5 days) are common as well. FWIW I recently moved from E3D to EOD, SQ.. All are better (in general) than once per week.
 
I rotate between 4 spots to try to avoid scar tissue 1" 25ga in the legs and insulin 1/2" 30ga in the shoulders I use Watson testosterone cypionate

for example right leg right shoulder left leg then left shoulder
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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