Testosterone & Fertility: Novel Techniques in Monitoring & Treating Hypogonadal Fertile Men: SERMs, hCG, rFSH, Aromatase Inhibitors

madman · Dec 20, 2025

Thread 'Preserving spermatogenesis in TD: innovations in replacement and stimulatory therapies'

Dec 20, 2025

* Fertility preservation remains an important consideration in the management of hypogonadal men. While exogenous testosterone therapy effectively alleviates symptoms, it suppresses the HPG axis and impairs spermatogenesis. Alternative therapeutic strategies—including short- acting formulations (intranasal and oral testosterone undecanoate), SERMs such as enclomiphene citrate, and concomitant administration of low-dose hCG—are under active investigation as potential options for maintaining or restoring fertility potential. Continued investigation and long-term outcome data...

madman · Dec 26, 2025

Thread 'Helen L. Bernie, DO, MPH, outlines clinical management of hypogonadism in fertility-desiring men'

Dec 26, 2025

* Finally, Bernie noted unresolved controversies in the field, including the optimal duration of fertility-preserving therapies, long-term outcomes of hybrid regimens combining testosterone with hCG, and best practices for sperm recovery after prolonged testosterone exposure. She emphasized the urgent need for larger, prospective, fertility-focused studies to guide future care.

Exogenous testosterone therapy and fertility are fundamentally incompatible.

In a talk at the 2025 Sexual Medicine Society of North America meeting in Grapevine...