Testosterone Effects on Mood

GreenMachineX

Well-Known Member
I’m having trouble understanding something. I’ve read on here that it takes weeks to really see a difference when adjusting dose and also that it takes some length of time for testosterone deficiency induced depression to lift. But, when talking about injections every 2 weeks, apparently it’s a roller coaster ride of acute ups and downs. Are both true?

Also, if I wait too long between doses, and my mood drops, is the inverse also true? If I have an event coming up that I need to be on my game for, could I dose just a little extra for a week around the event only to avoid prolonged elevated testosterone levels which could increase hct too much? This is all theoretical of course and in no way would I go against my doctors orders.
 
If your doctor has you in a every two week protocol....you need to find a new doctor.

There are soooooo many things that effect T doses and one guy might be fine on XYZ dose, while the next guy that same protocol does not work at all.
 
Thanks for the reply, but this was really the most important part of the opening post...
“If I have an event coming up that I need to be on my game for, could I dose just a little extra for a week around the event only to avoid prolonged elevated testosterone levels which could increase hct too much? This is all theoretical of course and in no way would I go against my doctors orders.”
 
Thanks for the reply, but this was really the most important part of the opening post...
“If I have an event coming up that I need to be on my game for, could I dose just a little extra for a week around the event only to avoid prolonged elevated testosterone levels which could increase hct too much? This is all theoretical of course and in no way would I go against my doctors orders.”
The swing should not be that great, it really shouldn’t affect your mood. If you feel that it is a big issue, just go to daily injections. Pretty simple.
 
Thanks for the reply, but this was really the most important part of the opening post...
“If I have an event coming up that I need to be on my game for, could I dose just a little extra for a week around the event only to avoid prolonged elevated testosterone levels which could increase hct too much? This is all theoretical of course and in no way would I go against my doctors orders.”
No offense, but MANY doctors are dunces, especially when it comes to TRT... I went through several and am still not 100% confident in my Endrocinologist or my Urologist who both are involved. I make my own decisions on dosage, HCT, number of injections/we, etc. Still not dialed in, but that is probably due to me changing dosage a few times.
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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