Testosterone Deficiency Focus of New Canadian Guidelines

Nelson Vergel

Founder, ExcelMale.com
From Medscape


Hypogonadism Algorythm.webp

The Canadian Men's Health Foundation has issued comprehensive new guidelines on the diagnosis and management of testosterone-deficiency syndrome in response to confusion in the literature about whether this syndrome even exists and whether testosterone-replacement therapy is safe.
Prior to developing the new guidelines, the Canadian Men's Health Foundation carried out a survey of Canadian physicians that suggested many are uncomfortable dealing with testosterone deficiency and uncertain about how to manage the condition.
"This was not surprising to someone like me, who has been interested in this subject for years, as a lot of the literature is very contradictory and there are very important differences of opinion in the management of testosterone-deficiency syndrome," guideline chair Alvaro Morales, MD, from the department of urology, Queen’s University, Kingston, Ontario, said in a podcast with CMAJ. The journal published the new guidelines October 26.
"Testosterone deficiency can occur at any age, but we are dealing mostly with men in whom there is decreasing testosterone production, who are most likely over the age of 45," Dr Morales noted in the podcast.

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In Canada, this is a significant step. That said, there is still an inability for most Canadian men to obtain the sensitive estradiol test (you'll note the flowchart does not even mention estradiol testing), and those of us who can travel to the States do so in order to obtain an accurate E2 value.

But it is something we have been waiting for as a reference that can be shown to general practitioners.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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