Testosterone Breakthrough: A New Testosterone Solution Rocking the HRT World

madman

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48:03: How to prescribe and access Kyzatrex

How to Prescribe


Through selected compounding and mail-order pharmacies, not at chain stores (CVS/Walgreens), keeping costs low and access high. Prescriptions are cash pay but often below compounding pharmacy prices—no insurance required.




Another perfect example of clinics dishing out those absurd 200 mg T/week protocols!

Still clueless!

26:15-36:52

elevated hematocrit/estradiol

* I see this more in men than in women because of the doses that we are giving them, so lets take the injectable testosterone cypionate we are going to dose a man at 200 mg/week whether he splits it up into micro-doses or does once a week dosing



LMFAO!


1761504332356.webp





Episode Overview

This episode explores the vital role of testosterone in both men and women, busts longstanding myths about hormone therapy, and spotlights a groundbreaking new oral testosterone option, Kyzatrex. Host Dr. Amie Hornaman and guest Shalin Shah (CEO of Marius Pharmaceuticals, makers of Kyzatrex) tackle why testosterone matters, the history and current state of testosterone replacement, common barriers to care, and how their new oral formulation overcomes previous safety and efficacy issues. Listeners get practical clinical insights and tools—whether you're a patient with low T or a clinician wanting to optimize hormone health for your patients.



Timestamps for Major Segments

  • 09:07: Why testosterone matters for men & women
  • 10:00: Brief history and current state of TRT
  • 13:14: Mental health and other benefits of T therapy
  • 18:04: Cardiovascular and prostate/cancer risk myths dispelled (TRAVERSE study)
  • 20:37: Regulatory barriers and insurance frustrations
  • 23:48: Activism: Fighting for testosterone descheduling
  • 27:46: The Kyzatrex difference – oral T with no liver toxicity
  • 31:39: Reduced estrogen conversion and side effects with Kyzatrex
  • 34:17: Impact on fertility and testicular function
  • 40:10: Role of SHBG and free testosterone optimization
  • 42:12–45:57: TRT for women and the challenges of current options
  • 48:03: How to prescribe and access Kyzatrex



Closing Thoughts

Dr. Amie and Shalin Shah stress the importance of patient empowerment, education for providers, and advocating against the stigma and regulatory obstacles that block access to optimal hormone health. Kyzatrex appears to offer a long-awaited, practical, and physiologically sound oral testosterone therapy—potentially a lifeline for millions of men and women.
 
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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