Testosterone and Insomnia

JWSimpkins

Member
Hey guys, my father has been on testosterone (compounded cream) 75 mg per day for 8 months and his doctor recently increased his dosage to 125 mg per day, and as a result he's been experiencing severe insomnia for the past week. Should he reduce the dosage or is this just an adjustment period where his body needs to get used to the new testosterone levels?
 
In older men, testosterone can be stimulatory. It can also increase sleep apnea. He should probably apply it in the morning and minimize his caffeine consumption after 3 pm and napping during the day.
 
I wonder if it is in part as basic as "because that is how we function naturally" - Testosterone levels decrease throughout the day and night and peak in the morning. When we administer at night, it is not consistent with normal function and confuses other systems??? Just a thought
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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