T3 and muscle loss

From AI
Overview
The liver plays a crucial role in metabolizing both thyroid hormones (T3 and T4) and testosterone. T3, the active form of thyroid hormone, is primarily converted from T4 in the liver. The liver also metabolizes testosterone, breaking it down into various products for excretion. While there's a complex interplay between thyroid hormone and liver function, including its impact on lipid metabolism and glucose regulation, there's less direct evidence of T3 specifically metabolizing testosterone in the liver. Instead, the liver's role is more about converting T4 to T3 and then metabolizing testosterone.
 
Cytomel can cause protein turnover in which the rate of protein degradation exceeds the rate of protein synthesis, leading to substantial muscle mass loss.
 
Excessive t3 will cause muscle loss. If you have hypothyroidism and you bring your levels back to normal, it can increase muscle.
also, when you running low on T3, the body will secrete more cortisol/adrenaline to compensate, that its self cause muscle loss
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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