Starting with Defy, Advice?

After being told by several doctors that my 307 Total T count is in the "normal" range (I'm 38yo and very active) I'm going to bite the bullet and work with Defy.

What questions should I have and is there anything I should be aware of? I'm trying to educate myself as much as possible through this process.
 
Do not use DHEA, or Pregnenolone, or an AI, at least in the beginning, and make sure that you understand your protocol and take notes. We've got multiple topics on the same subject if you search threads.
 
The problem with these reference ranges is they don't account for age, the normal testosterone levels for an elderly man is 300 ng/dL, president ***** is at 450 ng/dL at 72 year old.

The average testosterone levels for a 30 year old is 600-700 ng/dL, there is a conceded effort to keep men off of TRT and so the goal posts are moved to the levels at which disease will strike.

Fertility will be affected negatively, adding HCG and even FSH to a TRT protocol can improve fertility effectively. Beware there is a honeymoon phase when you first start TRT, you may feel amazing for a few weeks and then a crash, this is your pituitary shutting down and you must wait for your body to adapt.
 
Myself and my wife are with Defy.

Our advice....always consult and talk with the Doctors there.

Nothing against the PA and nurses, but we personally receive MUCH MORE advice and more thorough advice from the Doctors.

Each time we spoke with the nurses and PA, the advice was very....hmmm....basic and “canned” advice.

Again....this is just our opinion and you might do fine with the other staff.

Good luck.
 
I am a start low and go slow kinda guy, believing in the lowest amount of any med to get where i need to be. As Vince Cartermentioned, i woul dnot start on several meds all at once, in fact i did not when they gave me my first protocol. There is so much variation from one guy to the next that a cookie cutter approach does not work. My reasoning is if i take several new things at once, how do i know what each one did. I prefer to isoloate. Just my approach, others may vary
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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