Should I switch out my hcg

Hi there. I’ve been in trt for a year using gels two pumps daily. Also was using hcg twice a week. My challenge is that my E2 levels are really high compared to where I started and although they are not in the clinical danger zone I do find I’m having some issues ie no erections, feeling slightly emotional and sensitive nipples. I did take DIM to reduce E previously and it worked. I’m wondering if I switched from hcg and took enclomiphine along with DIM this would lower my E and prolactin levels to get rid of the negatives mentioned. Other than those things I feel awesome with my T levels as they currently are. I’ve attached my lates results, any thoughts feedback appreciated.
FSH 3.3IU/L
LH 3.3IU/L
Oestradiol 145pmol
Testosterone 26.7nmol
Free T 0.72nmol
Prolactin 224mIU
 
I’m wondering if I switched from hcg and took enclomiphine along with DIM this would lower my E and prolactin levels to get rid of the negatives mentioned.
Clomid would likely make things worse in place of TRT, because it blocks estrogen in the brain, so it’s common to have little or no libido.

Your estrogen will be higher on clomid. If you start clomid while on TRT, it likely won’t do anything except block estrogen in the brain.

Also, side effects wise, clomid is on average worse compared to TRT and hCG.

So no need to make things more complicated, keep it simple, decrease the hCG dosage.
 
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Thanks for the input. Thinking about introducing Calcium D Glucarate and use DIM again as previously DIM reduced my E numbers after a month. I think you’re right in reducing the HCG dosage as this seemed to have been what pushes my E up. Anyone had experience of Calcium D Glucarate and DIM combined. Again my numbers aren’t crazy bad on the E front but the way I feel is what’s driving the investigation to bring E down. I doubt my doc would prescribe an AI seeing as my T to E ratio is ok (I think), but I’m seeing them tomorrow and will ask.
Thanks again for feedback any more us welcome.
 
neither DIM or calciium gluconate reduced my e2 sensitive at all. could it be that they remove other estrogens from the body and leave 2 untouched? maybe high e2 isn't an issue but the other/synthetic estrogens are. i remember seeing a podcast with Danny Bossa talking about this with a doc. I have no problems with an e2 of 60-70. however i did clean up some of my cosmetics and stopped using fragranced shampoos/showergels etc. i used to have issue with any HCG dose where it would give me anxiety, but somehow this is gone now and my dose is 3x1000iU or higher.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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