Starting semorelin, but concerned because I have high e2 and SHBG. Last test was total T over 1500, free T 17, e2 53 (sensitive) 60 regular, and 60 SHBG.
Last week I lowered my subQ TRT dose from .3cc x2 to .25 x2 (100mg). Not sleeping great and not sure I feel optimal with these high numbers.
Should I lower my TRT to 80mg weekly? As a reference when I was on enclomophine 6.25 EOD I was 900+. Not sure if that response is indictive of TRT response but I feel like I'm responding to small doses.
Thoughts?
Need more to chew on here!
What is critical here is how many days post-injection was blood work done let alone what assay was used for one of the most critical blood markers free testosterone.
We always want to test at the true trough (lowest point) before your next injection which in your case would be 3.5 days (84 hrs) post-injection seeing as you are injecting twice-weekly.
Although TT is important to know free testosterione is what truly mattres as it is the active unbound fraction of T responsible for the positive effects.
If you were hitting a whopping TT 1500+ ng/dL then it would have been tested using the standard immunoassay which caps out at 1500 ng/dL.
You would need to have had it tested using the most accurate assays (LC/MS-MS) to know where it truly sits.
In order to know where your FT truly sits you would need to have it tested using the most accurate assay the gold standard Equilibrium Dialysis especially in cases of altered SHBG.
Highly doubtful you tested your FT using ED as there is no way you are only hitting a FT 17 ng/dL with a whopping TT 1500+ ng/dL even with a high SHBG 60 nmol/L.
If we just use a whopping TT 1500 ng/dL, high SHBG 60 nmol/L and Albumin 4.3 g/dL (default) and calculate your FT using the linear law-of-mass action Vermeulen (cFTV) your FT 28.1 ng/dL would be very high.
Throw in a 1500+ ng/dL and your FT would be even higher!
