Should I lower my trt dose starting semorelin?

[Sandz]

Starting semorelin, but concerned because I have high e2 and SHBG. Last test was total T over 1500, free T 17, e2 53 (sensitive) 60 regular, and 60 SHBG.

Last week I lowered my subQ TRT dose from .3cc x2 to .25 x2 (100mg). Not sleeping great and not sure I feel optimal with these high numbers.

Should I lower my TRT to 80mg weekly? As a reference when I was on enclomophine 6.25 EOD I was 900+. Not sure if that response is indictive of TRT response but I feel like I'm responding to small doses.

Thoughts?

 

[madman]

Starting semorelin, but concerned because I have high e2 and SHBG. Last test was total T over 1500, free T 17, e2 53 (sensitive) 60 regular, and 60 SHBG.

Last week I lowered my subQ TRT dose from .3cc x2 to .25 x2 (100mg). Not sleeping great and not sure I feel optimal with these high numbers.

Should I lower my TRT to 80mg weekly? As a reference when I was on enclomophine 6.25 EOD I was 900+. Not sure if that response is indictive of TRT response but I feel like I'm responding to small doses.

Thoughts?

Need more to chew on here!

What is critical here is how many days post-injection was blood work done let alone what assay was used for one of the most critical blood markers free testosterone.

We always want to test at the true trough (lowest point) before your next injection which in your case would be 3.5 days (84 hrs) post-injection seeing as you are injecting twice-weekly.

Although TT is important to know free testosterione is what truly mattres as it is the active unbound fraction of T responsible for the positive effects.

If you were hitting a whopping TT 1500+ ng/dL then it would have been tested using the standard immunoassay which caps out at 1500 ng/dL.

You would need to have had it tested using the most accurate assays (LC/MS-MS) to know where it truly sits.

In order to know where your FT truly sits you would need to have it tested using the most accurate assay the gold standard Equilibrium Dialysis especially in cases of altered SHBG.

Highly doubtful you tested your FT using ED as there is no way you are only hitting a FT 17 ng/dL with a whopping TT 1500+ ng/dL even with a high SHBG 60 nmol/L.

If we just use a whopping TT 1500 ng/dL, high SHBG 60 nmol/L and Albumin 4.3 g/dL (default) and calculate your FT using the linear law-of-mass action Vermeulen (cFTV) your FT 28.1 ng/dL would be very high.

Throw in a 1500+ ng/dL and your FT would be even higher!

Free & Bioavailable Testosterone calculator

 

[Sandz]

Sorry. I'm new/learning.

Albumin was 4.4.
Free was 17.3
Test was 7hrs, Friday fasted, short inwa the day am, 3 days.
Next time I'll have to test the more sensitive but it's a good baseline and it all I've evee tested till now because I didn't know better. My doc is ok, but I find you have to be your own advocate so now I know.

Any thoughts on semorelin though (started last night) or lowering my dose of TRT? I'm just not feeling as good as I was on the way up or almost before.....I'm stronger, but puffier, less sleep, and odd digestion which is kinda what happened when I was on enclo and stopped.

 

[madman]

Sorry. I'm new/learning.

Albumin was 4.4.
Free was 17.3
Test was 7hrs, Friday fasted, short inwa the day am, 3 days.
Next time I'll have to test the more sensitive but it's a good baseline and it all I've evee tested till now because I didn't know better. My doc is ok, but I find you have to be your own advocate so now I know.

Any thoughts on semorelin though (started last night) or lowering my dose of TRT? I'm just not feeling as good as I was on the way up or almost before.....I'm stronger, but puffier, less sleep, and odd digestion which is kinda what happened when I was on enclo and stopped.

Post a screenshot of your lab results.

What days are you injecting and are you saying that blood work was done 7 hrs or 3 days post-injection?

You do not need to fast when using exogenous T.

Natties need to test in the early am in a fasted state otherwise the resuts would be skewed.

Again all you really know is that your TT was absurdly high and even then we have no clue how high it was as you had it tested using the standard immunoassay which caps out at 1500 ng/dL.

You would need to have had it tested using the most accuaret assay LC/MS-MS to know where it truly sat.

Even more critical is you have no clue where your free testosterone sat as it is highly doubtful it was tested using the most accuarte assay Equilibrium Dialysis as there in no way your FT is 17 ng/dL with a whopping TT 1500 let alone 1500+ ng/dL even with having a high SHBG 60 nmol/L.

Need to know where your TT let alone FT truly sat at true trough (lowest point) before your next injection on such protocol (dose of T/injection frequency) before even deciding whether your dose may need to be tweaked.

Again big difference between on hitting a high/very high TT/FT at peak vs trough!

Top it off that you are missing critical blood markers RBCs, hemoglobin and hematocrit.