SHBG Effect on TT, FT and DHT

DJ87

Member
Hey guys,

I am going to be trying NDT in the near future to increase my low thyroid numbers and am hoping a side effect may be increased SHBG from what other members have experienced. That said my TT is 1100, FT 29 and DHT 60. Right now my SHBG sits around 16. Say it increases to 30 what kind of effect would I see on my overall numbers? I am injection test cypionate at 150mg a week currently. To keep similar numbers do you believe I would need to increase that amount?
 
In theory your free testosterone won't change. Total testosterone should go up. Predicting by how much depends on which free T calculator is more accurate. Assuming default albumin, Vermeulen says TT jumps to 1,320 ng/dL, while Tru-T puts it at only 1,145. Sartorious says 1,430. I think I'd bet on Vermeulen in this case.
 
Hey guys,

I am going to be trying NDT in the near future to increase my low thyroid numbers and am hoping a side effect may be increased SHBG from what other members have experienced. That said my TT is 1100, FT 29 and DHT 60. Right now my SHBG sits around 16. Say it increases to 30 what kind of effect would I see on my overall numbers? I am injection test cypionate at 150mg a week currently. To keep similar numbers do you believe I would need to increase that amount?
How do you feel with that dose and those numbers ?
 
How do you feel with that dose and those numbers ?
Feel good, I have been on this protocol for about 10 months. The only negative that I have some high E2 symptoms. I am not on an AI and my E2 runs around 40(standard Lab Corp ranges). Seems like people have reported some great success getting their SHBG and E2 the same or around that ballpark and it would be a good side effect from the thyroid boost that I need...at least from a T3 perspective.
 
Feel good, I have been on this protocol for about 10 months. The only negative that I have some high E2 symptoms. I am not on an AI and my E2 runs around 40(standard Lab Corp ranges). Seems like people have reported some great success getting their SHBG and E2 the same or around that ballpark and it would be a good side effect from the thyroid boost that I need...at least from a T3 perspective.
Awesome. What's your injection frequency
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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