Sex Hormone-Binding Globulin (SHBG): Biology and Biomarker

[madman]

Nelson's house!

We get deep here!

Dr. Winters!

 

[madman]

Schematic model of the human SHBG gene and protein

 

[madman]

SHBG in newborns

Males/Females - Age/SHBG (nmol/L)

 

[madman]

Thyroxin increases SHBG

 

[madman]

Ontogeny of hormone levels in males

Salivary Testosterone during the MiniIpuberty of Infancy

Reference curves based on 2139 Healthy Norwegian Children

 

[madman]

* its one of the reasons why some people disparage calculating free testosterone from the SHBG and Testosterone level, there's a formula to do that and its based on having the affinity of the SHBG for Testosterone but if the affinity isn't always the same they argue that the equation really applies to most people but not to all people and therefore they propose the direct HPLC analysis to measure free testosterone and that's sort of becoming the standard affair because this objection has sort of permeated in the literature




Naturally occurring SHBG mutants

 

[madman]

Relationship between plasma SHBG and total testosterone

The testosterone feedback loop is a negative feedback system that regulates testosterone levels in the body, controlled by the hypothalamus-pituitary-gonadal (HPG) axis.




The HPG Axis and Negative Feedback

"Free Hormone Hypothesis"

 

[madman]

Conditions that influence the level of SHBG in plasma

 

[madman]

Hormone Levels in Hyperthyroid Men

SHBG and inappropriate TSH secretion

 

[madman]

Low serum testosterone and sex-hormone-binding globulin in massively obese men

SHBG and obesity in adult men

 

[madman]

Metabolic factors are major determinants of SHBG beginning in newborns on day 2

 

[madman]

SHBG levels with obesity in early puberty

 

[BadassBlues]

SHBG without question is one of the most least understood aspects of hormonal function. Great post!

 

[madman]

Level of SHBG is positively correlated with insulin sensitivity in men with T2 diabetes

 

[madman]

Obesity and SHBG in women with PCOS

 

[madman]

SHBG in Men with MetS

SHBG in Women with MetS

MetS and SHBG in Spanish adolescents ages 12-16

Characteristics MASLD adolescent girls with PCOS