I ordered and have selegiline. However, I am hesitant to take it since its really for parkinsons. So I tried wellbutrin first
sensitivity issue can't solve
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Im 44. I do have selegiline on hand. But I was hesitant to take it since its for parkinsons
So i wanted to try Wellbutrin first and definitely won't be taking both at the same time. What's your dosage on selegiline and frequency. How long have you been on it?
My approach is overly complex and impractical for most; it involves multiple daily injections. It's much simpler to first try significant dose reductions, and if no luck there then try switching to a short-acting form of testosterone, as these resolve hypogonadism with less hormonal chaos than conventional TRT. Your current TRT dose is likely still on the order of double what your healthy natural production would be, which is around 5-7 mg of testosterone daily. This corresponds to 50-70 mg of testosterone cypionate weekly. Excessive testosterone can have negative effects on 20-30+ other hormones and neurotransmitters. My discussion of two of the most directly affected hormones:
In any case, if you can switch to short-acting TRT then your hormones operate closer to normal, reducing the risk of side effects. Short-acting testosterone includes nasal gels, buccal troches and possibly certain oral formulations. The former two are the best proven, but are less convenient. A trial could at least establish whether the approach is helpful to you. These forms of TRT are simpler than trying to directly replace the suppressed GnRH with gonadorelin and the suppressed kisppeptin with kisspeptin-10.
Read some other accounts of the misery caused by excessive TRT dosing:
Especially this one:
I appreciate that.My approach is overly complex and impractical for most; it involves multiple daily injections. It's much simpler to first try significant dose reductions, and if no luck there then try switching to a short-acting form of testosterone, as these resolve hypogonadism with less hormonal chaos than conventional TRT. Your current TRT dose is likely still on the order of double what your healthy natural production would be, which is around 5-7 mg of testosterone daily. This corresponds to 50-70 mg of testosterone cypionate weekly. Excessive testosterone can have negative effects on 20-30+ other hormones and neurotransmitters. My discussion of two of the most directly affected hormones:
In any case, if you can switch to short-acting TRT then your hormones operate closer to normal, reducing the risk of side effects. Short-acting testosterone includes nasal gels, buccal troches and possibly certain oral formulations. The former two are the best proven, but are less convenient. A trial could at least establish whether the approach is helpful to you. These forms of TRT are simpler than trying to directly replace the suppressed GnRH with gonadorelin and the suppressed kisppeptin with kisspeptin-10.
Read some other accounts of the misery caused by excessive TRT dosing:
Especially this one:
But that begs the question.
I'm on 110mg of cyp a week right now.
Putting my total at trough around 700-750, and my free T at the upper end of the range.
If I half my dose. What's the point of being on TRT?
Most that get on T, are looking to get to the upper end of the normal range.
I was making between 200-300 total T, before TRT. Why would I half the dose to go down there again?
Maybe I should just come off and see if I can get my low natural going again.
If i half my dose. I'm sure my total T will drop below 500 or so.
The point of being on TRT is to treat hypogonadism and thereby improve overall health. If you had started with above-borderline natural free testosterone then most likely there would have been no point in being on TRT. The high-dose apologists may point to some rare conditions where functional hypogonadism exists in spite of seemingly normal testosterone levels. However, these are so uncommon that I don't think I've encountered a single documented case in the forums.
In any case, because you were hypogonadal originally, successful treatment does not require high-end trough testosterone and supraphysiological peaks. This is simply asking for side effects. What you're looking for is the level/variation in levels that gives you the best results overall. This is likely going to be in the physiological range—maybe in the vicinity of your healthy youthful levels—and low-and-slow dosing is a tried-and-true approach. While both dose increases and dose decreases can cause transient misleading effects, dose increases are usually more pleasant, and limiting the rate of increase minimizes spurious results.
That's because of the widespread more-is-better delusion surrounding testosterone. Sometimes it's encouraged by unscrupulous doctors, but more charitably doctors are often responding to patient demand.
If enhanced musculature and athleticism is a priority over general health then more testosterone is indeed better. But let's not pretend that such dosing is TRT.
You're looking to have heathy levels. Naturally occurring morning total testosterone of 200-300 ng/dL implies low free testosterone and hypogonadism unless you had rock-bottom SHBG. Having a trough testosterone around 500 ng/dL on TRT is still a gigantic increase. TRT peaks on two injections per week are likely to be at least 40-50% higher than troughs, e.g. 700-800 ng/dL. Don't think for a moment that these levels are not worth trying. In my opinion, such levels should have been tried at the start, not as a fall-back after having problems with excess.
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