Scrotum application of testosterone

[BigJohn]

There seems to be some controversy as to whether you can apply testosterone cream on the scrotum. There's a company in Australia that reccomends it. I can't seem to find any real reason not to do it. I have been applying on mine for several days and I do seem to feel better and also seems to raise my libido. Any thoughts?

 

[Nelson Vergel]

For men with poor DHT response when on testosterone, using special creams that you can rub on testicles works at increasing DHT more effectively. Because of the high 5 alpha-reductase activity in the scrotal skin, blood DHT levels are above the upper normal range. DHT is linked to sex drive and many of the benefits (and some of the side effects like acne and hair loss) are attributed to this testosterone metabolite. This caused concern that prostate disease could develop. However, in hypogonadal patients treated for up to 10 years with the trans scrotal films, no untoward side-effects developed.

A few of the guys on here use a special compounded cream that does not burn your scrotum (Androgel, Testim, Axiron, and Fortesta can burn that area, so do not use them!). My DHT is good enough, so I do not use it.

 

[Gene Devine]

It's funny, I had a renowned TRT Doc say to me one time that "we say we supplement with Testosterone when what we really should be saying is we increase DHT levels!"

DHT is 8 times more androgenic than testosterone and what really makes us men!

 

[BigJohn]

I use a compounded cream so it doesn't burn. So far I would say that I'm pleased with the results so far.

 

[Peter Luscombe]

I'm on Tostran Gel @ 2% and have (USA make!!) Mentor 3005 prosthetic testicles fitted after an accident at work. I am always looking for better application sites so am I right in assuming it's pointless for me or should I try it anyway? Comments (even droll ones) appreciated.

 

[Keith Willse]

I believe it should only be used this way, if DHT is low. I also believe it should not be used this way long term. DHT is king and all things male but too much will have diminishing returns and nasty side effects.
In my experience, its best used in conjunction with HCG mono. It can bring the benefits that increased testosterone levels don't always bring when using HCG mono alone. When used this way, it should be compounded in a low dose Lidoderm based cream. It can also be added to a injection TRT routine but in a low dose, every other day for the DHT benefit only.

 

[BigJohn]

Would you suggest a DHT test?

 

[Keith Willse]

Yes, I would run the test from Quest or LabCorp. I personally like Quest for this lab but it’s just a preference with this particular lab.
http://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=90567

 

[skycop00]

Study is from 2017

 

[Nelson Vergel]

Study is from 2017

Great paper. Thanks!

Previous posts on scrotum application of testosterone cream on ExcelMale.com

 

[skycop00]

Great paper. Thanks!

Most current one to my knowledge! Nice data to have for sure. I switched to cream in ATREVIS base gel and am very pleased!

 

[Nelson Vergel]

One of our members have had great results using scrotum application:

Successful Story with Testosterone Cream Protocol

 

[Vince Carter]

Cream to the scrotum works really well for me from a purely DHT standpoint, testing verified. My baseline was about 35-40 on a 16-79 scale. Application of 2 clicks @ 2 hours prior to a blood draw saw my DHT rise to ~100. I also testing verified returned to baseline 24hrs later. Never monitored this for Test or E purposes, only DHT as I continued using Cypionate and Anastrozole.

I think 2 clicks is 25mg IIRC

If I EVER had to get off Cyp injections I think I'd go to cream on the scrotum application exclusively.

 

[skycop00]

Good info Vince! I am dosing 2x a day and between 100-150 mg per application. Atrevis gel I prefer over the HRT base as well. I will run new labs Wed. about 4-5 hours post AM application. I have my pre-cream labs ready to compare. Based on feel and sense of well being it's outstanding! Dosing 2x per day can be a hassle based on activity and workouts, that has been the only issue so far...

 

[Nelson Vergel]

Case Study: Absorption of Testosterone Cream via Scrotal Delivery

 

[Nelson Vergel]

Andrology. 2017 Jul;5(4):725-731. doi: 10.1111/andr.12357. Epub 2017 Mar 23.

Pharmacokinetics of testosterone cream applied to scrotal skin.

Iyer R1, Mok SF1, Savkovic S1, Turner L1, Fraser G1, Desai R1, Jayadev V1, Conway AJ1, Handelsman DJ1.


Abstract
Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-over pharmacokinetic study of three single doses (12.5, 25, 50 mg) of testosterone cream administered in random sequence on different days with at least 2 days between doses to healthy eugonadal volunteers with endogenous testosterone suppressed by administration of nandrolone decanoate. Serum testosterone, DHT and estradiol concentrations were measured by liquid chromatograpy, mass spectrometry in extracts of serum taken before and for 16 h after administration of each of the three doses of testosterone cream to the scrotal skin. Testosterone administration onto the scrotal skin produced a swift (peak 1.9-2.8 h), dose-dependent (p < 0.0001) increase in serum testosterone with the 25 mg dose maintaining physiological levels for 16 h. Serum DHT displayed a time- (p < 0.0001), but not dose-dependent, increase in concentration reaching a peak concentration of 1.2 ng/mL (4.1 nm) at 4.9 h which was delayed by 2 h after peak serum testosterone. There were no significant changes in serum estradiol over time after testosterone administration. We conclude that testosterone administration to scrotal skin is well tolerated and produces dose-dependent peak serum testosterone concentration with a much lower dose relative to the non-scrotal transdermal route.

 

[Nelson Vergel]

Should You Apply Testosterone Gel or Cream on Your Testicles for Best Absorption?

 

[Sterling]

Should You Apply Testosterone Gel or Cream on Your Testicles for Best Absorption?

For those of us interested in using this delivery system, how do we go about controlling DHT to help combat hair loss?

 

[Vince Carter]

For those of us interested in using this delivery system, how do we go about controlling DHT to help combat hair loss?

hairloss and MPB are much more about genetics than hormonal but if you have that history of youreself or male family members it can be a concern. There are or a product called Nizoral that is OTC shampoo which has a fair reputation for preventing hairloss.

 

[skycop00]

For those of us interested in using this delivery system, how do we go about controlling DHT to help combat hair loss?

For those of us interested in using this delivery system, how do we go about controlling DHT to help combat hair loss?

That's simple... You don't!!! Allow it to rise as the prostate has Intr-prostatic control mechanism. If you're doing BID you should reach somewhere between 300-500. Hope that helps...