Safety Study for 300mg of Test a Week

[Jda016]

I recently came across a study from 1990, where men were taking 25, 50, 100, and 300 mg of test a week for 6 months. The study concluded that "we found no evidence of major adverse health effects of T administered chronically even at the highest dosage." However, they did notice higher hematocrit in the men with 300 T, but did not consider that a "major adverse health effect."

Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing hormone, follicle-stimulating hormone, and sperm production - PubMed

In normal men, chronic testosterone (T) administration results in negative feedback suppression of gonadotropin and sperm production. However, azoospermia is achieved in only 50-70% of men treated with high dosages of T. Furthermore, the relative sensitivity of LH and FSH secretion to chronic...

pubmed.ncbi.nlm.nih.gov

I am curious how 300mg of test could be considered safe, when it clearly would bring the majority of men to supraphysiological levels. Is this evidence that 300mg is truly sustainable, or would major adverse health risks take years to appear? Did the study simply get "lucky" in terms of not having any men have adverse effects? Honestly, I find their conclusions confusing when I hear that 300mg of test a week is considered a "steroid cycle" by many people.

Any thoughts or insights on this?

 

[madman]

I recently came across a study from 1990, where men were taking 25, 50, 100, and 300 mg of test a week for 6 months. The study concluded that "we found no evidence of major adverse health effects of T administered chronically even at the highest dosage." However, they did notice higher hematocrit in the men with 300 T, but did not consider that a "major adverse health effect."

Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing hormone, follicle-stimulating hormone, and sperm production - PubMed

In normal men, chronic testosterone (T) administration results in negative feedback suppression of gonadotropin and sperm production. However, azoospermia is achieved in only 50-70% of men treated with high dosages of T. Furthermore, the relative sensitivity of LH and FSH secretion to chronic...

pubmed.ncbi.nlm.nih.gov

I am curious how 300mg of test could be considered safe, when it clearly would bring the majority of men to supraphysiological levels. Is this evidence that 300mg is truly sustainable, or would major adverse health risks take years to appear? Did the study simply get "lucky" in terms of not having any men have adverse effects? Honestly, I find their conclusions confusing when I hear that 300mg of test a week is considered a "steroid cycle" by many people.

Any thoughts or insights on this?

The Matsumoto study from 1990.

It was a short-term study (6 months) and the treatment group using 300 mg T/week was n = 10!

10 men!

In the short-term considered safe as there was no significant adverse health effects or sides other than increased hematocrit, mild truncal acne and water retention as some of the weight gain would have been intra/extra cellular water.

Any negative impact on cardiovascular health when abusing T/AAS would take much longer and there are many other factors involved here.

Age, genetics, lifestyle (diet, exercise, sleep, stress), and cardiovascular/overall health markers

Even then 300 mg T/week is not therapeutic and well beyond what a man would need when on testosterone therapy.

Most men on therapy are injecting 100-200 mg T/week whether once weekly or split into more frequent injections.

Let me be very clear here the majority of men can easily achieve a healthy/high trough FT injecting 100-150 mg T/week especially when split into more frequent injections.

Yes there will always be those outliers who may need the higher-end dose 200 mg T/week but its far from common as in rare.

200 mg T/week would have the majority of men overmedicated!

Rare most would even need to go above 150 mg T/week.

Keep in mind there are also some men who can achieve stellar levels injecting <100 mg T/week especially when split into more frequent injections.

Most men abusing T for the sole purpose of muscle/strength gains are banging 400-600 mg T/week.

Many would consider 300 mg T/week as getting your feet wet!

Post in thread 'Brand vs generic testosterone'

Mar 28, 2024

Off topic madman, but you know your stuff! What’s your thoughts on healthiest way to live longest while maintaining some decent lean muscle, ie, like a goal of TT around 1100, or more like 600 and be meh but live a longer life?

Too many factors at play here.

Quality sleep, healthy hormones, positive mental state, minimizing stress (physical/mental), optimum nutrition, exercise/maintaining a healthy body weight, minimize use of medications, avoid smoking and abuse of drugs/alcohol/anabolic steroids.

Unfortunately we live in a toxic environment.

Genetics plays a huge role...

• madman

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